The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer

Author(s): Jiayuan Qu, Mohammad Amjad Kamal, Chengfu Yuan*

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 8 , 2019

Become EABM
Become Reviewer
Call for Editor


Background: Ovarian cancer is the most malignant tumor in gynecological tumors, with low five-year survival rate. The main reasons are diagnosis at advanced stages (the early symptoms are uncharacteristic, and most are diagnosedlate.), relapse, and resistance to existing chemotherapy drugs.

Methods: Search strategy was performed in the following steps. Firstly, LncRNA related to ovarian cancer was retrieved by using the LncRNA Disease database, and articles were searched by searching keywords: ovarian cancer, drug resistance, and LncRNA retrieved from the LncRNA Disease database.

Results/Conclusion: With the development of the study on drug resistance of ovarian cancer, the role of LncRNAs as sensitive biomarker and therapeutic target has emerged, providing a direction for precision medicine of ovarian cancer resistance.

Keywords: Ovarian cancer, chemoresistance, long non-coding RNA, LncRNA, drug resistance, gynecological tumors.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2019
Published on: 19 June, 2019
Page: [856 - 861]
Pages: 6
DOI: 10.2174/1381612825666190404122154
Price: $65

Article Metrics

PDF: 54
HTML: 11
PRC: 1