The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer

Author(s): Jiayuan Qu, Mohammad Amjad Kamal, Chengfu Yuan*

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 8 , 2019


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Abstract:

Background: Ovarian cancer is the most malignant tumor in gynecological tumors, with low five-year survival rate. The main reasons are diagnosis at advanced stages (the early symptoms are uncharacteristic, and most are diagnosedlate.), relapse, and resistance to existing chemotherapy drugs.

Methods: Search strategy was performed in the following steps. Firstly, LncRNA related to ovarian cancer was retrieved by using the LncRNA Disease database, and articles were searched by searching keywords: ovarian cancer, drug resistance, and LncRNA retrieved from the LncRNA Disease database.

Results/Conclusion: With the development of the study on drug resistance of ovarian cancer, the role of LncRNAs as sensitive biomarker and therapeutic target has emerged, providing a direction for precision medicine of ovarian cancer resistance.

Keywords: Ovarian cancer, chemoresistance, long non-coding RNA, LncRNA, drug resistance, gynecological tumors.

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Article Details

VOLUME: 25
ISSUE: 8
Year: 2019
Published on: 18 June, 2019
Page: [856 - 861]
Pages: 6
DOI: 10.2174/1381612825666190404122154
Price: $65

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