Early Diagnosis of Cancer using Nuclear Magnetic Resonance Spectroscopy: A Novel Diagnostic Approach
Pp. 164-185 (22)
Neetu Talreja, Manjula Nair and Dinesh Kumar
Cancer is an abnormal growth of cells in the body that spread through the
organs and leads to health complications and sometimes, death. The most important
challenge is to develop strategies for diagnosing and monitoring the risk of cancer,
thereby effectively treating cancer patients.
Mutations in cancer genes and alterations in signals from cells might trigger a change
in the metabolism. Metabolites represent the end products of complex metabolic
pathways. The metabolome reflects changes by cancerous cells in cell cycle pathways,
thereby providing a logical approach for cancer diagnosis. Specific changes in the
metabolome are thought to reflect pathological states of patients. Based on the grade of
degeneration, tumor cells show alterations in basic biochemical processes. The
metabolic signature of malignancy and precursor cells in cancer metabolic reaction
might provide an indication for the presence of cancer. In general, measuring the
metabolites in cancer patients might be an effective strategy for early diagnosis of
Nuclear magnetic resonance (NMR) is a promising method for measuring
concentrations of metabolites in complex samples with good reproducibility, high
sensitivity, and simple sample processing. A positive aspect of NMR is that samples
are not destroyed by the process; hence they can be analyzed in other ways too. In this
chapter, we summarize the uses of NMR spectroscopy in early diagnosis of cancer
diseases as well as future prospects of this technique.
Cancer, Diagnosis, Metabolomics, Magnetic Resonance, Nuclear.
School of Chemical Sciences, Central University of Gujrat, Gandhinagar 382030, India.