Efficient and Regioselective Ring-opening of Epoxides with Carboxylic Acid Catalyzed by Graphite Oxide

Author(s): Maryam Mirza-Aghayan*, Mahdieh Molaee Tavana, Elaheh Golam Alipour Niazi, Rabah Boukherroub

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 7 , 2020

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Graphical Abstract:


An efficient, simple and regioselective ring-opening reaction of epoxides with various carboxylic acids under metal-free conditions is reported. The ring-opening of epoxides takes place in the presence of graphite oxide as an efficient and available catalyst to produce the corresponding 2-hydroxy monoester and 1,2-diester derivatives in good yields. Regioselective attack of the nucleophile, short reaction times, metal-free conditions and reusability of catalyst are among the advantages of the present protocol.

Keywords: Ring-opening, epoxides, carboxylic acids, metal-free conditions, graphite oxide, 1, 2-diester.

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Article Details

Year: 2020
Page: [532 - 538]
Pages: 7
DOI: 10.2174/1570178616666190401194252
Price: $65

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