An efficient, simple and regioselective ring-opening reaction of epoxides with various carboxylic
acids under metal-free conditions is reported. The ring-opening of epoxides takes place in the
presence of graphite oxide as an efficient and available catalyst to produce the corresponding
2-hydroxy monoester and 1,2-diester derivatives in good yields. Regioselective attack of the nucleophile,
short reaction times, metal-free conditions and reusability of catalyst are among the advantages
of the present protocol.
Keywords: Ring-opening, epoxides, carboxylic acids, metal-free conditions, graphite oxide, 1, 2-diester.
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