Background: Current guidelines recommend the use of vancomycin for the initial treatment
of moderate to severe Clostridioides difficile Infection (CDI). Surotomycin, a novel antibiotic,
has been utilized for the management of CDI with variable results.
Methods: A systematic literature search was performed using the following electronic databases
[Medline, Embase, google scholar and Cochrane] for eligible studies. Randomized controlled trials
comparing Surotomycin with Vancomycin for the CDI treatment were included. Demographic variables
and outcomes (CDI resolution, CDI recurrence, B1/NAP1/027-specific strain treatment,
B1/NAP1/027-strain recurrence, death not related to treatment) were analyzed. The primary outcome
was clinical cure rate defined as the resolution of CDI at the end of the 10-day drug course.
Results: Three RCTs met the inclusion criteria with a total of 1280 patients with CDI who received
either surotomycin 250 mg twice daily (642 patients) or vancomycin 125 mg four times daily (638
patients). Clinical cure rates after 10 days of treatment with either surotomycin or vancomycin were
not significantly different (pooled OR: 0.89, 95% CI 0.66-1.18, p=0.41). Sustained clinical response
at clinical follow-up and the overall recurrence of CDI were also not significantly different between
the two groups – pooled OR 1.15 (95% CI 0.89-1.50, p=0.29) and pooled OR 0.74 (95%CI 0.52-
1.04, p=0.08), respectively. With regards to the NAP1/BI/027 strain, patients in the surotomycin
group had significantly lower rates of recurrence compared to vancomycin (pooled OR 0.35, 95%
CI 0.19-0.63, p<0.01).
Conclusion: Surotomycin is non-inferior to vancomycin and offers a promising alternative for the
treatment and prevention of C. diff infection.