Obesity and Body Composition in Man and Woman: Associated Diseases and the New Role of Gut Microbiota

Author(s): Ennio Avolio*, Paola Gualtieri, Lorenzo Romano, Claudio Pecorella, Simona Ferraro, Giuseppe Palma, Laura Di Renzo, Antonino De Lorenzo

Journal Name: Current Medicinal Chemistry

Volume 27 , Issue 2 , 2020


DOI : 10.2174/0929867326666190326113607

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Abstract:

Background: Obesity is now recognized as a worldwide health issue and has reached epidemic proportions, affecting both developed and developing countries. The World Obesity Federation stated that “Obesity is a chronic relapsing disease process”: as a result, obesity has been recognized internationally as a chronic disease.

The primary cause of the metabolic syndrome and increase of the cardiovascular risk have been identified in "sick fat", a condition then defined as adiposopathy. Heart attacks, strokes and renal failures are pathologies that have mid-risk factors such as dyslipidemia, hypertension and diabetes, which in turn are caused by obesity, whose primary risk factor is represented by the diet. The aim of the present review is to consider the importance of body composition, together with chronic inflammation and a new gut microbiota data that may turn out to be crucial elements of some target treatment of human obesity.

Methods: In this review, we performed research using PubMed database reviewing the evidence in the literature of evidence information regarding the link between obesity and body composition in the development of metabolic disease via inflammation markers and in particular, the new role exerted by gut microbiota.

Results: Several papers were evaluated searching for differences in fat mass and disease risk. We also identified the same papers dealing with differences in body composition and metabolic syndrome. Our attention focuses also on a new frontier of gut microbiota composition in the body weight decrease and anti-inflammatory effects.

Conclusion: To the saving of lean mass, for the prevention of cardiometabolic diseases, also considering the relationship with obesity, it is necessary to reduce the inflammatory state, acting on the gut-microbiota and on the intestinal permeability. To improve the health of the intestinal flora, we propose a 4P medicine and treatment with probiotics, prebiotics, postbiotics, and polyphenols.

Keywords: Obesity, body composition, inflammation, metabolic disease, gut microbiota, adiposopathy.

[1]
Bays, H. Adiposopathy, “sick fat,” Ockham’s razor, and resolution of the obesity paradox. Curr. Atheroscler. Rep., 2014, 16(5), 409.
[http://dx.doi.org/10.1007/s11883-014-0409-1] [PMID: 24659222]
[2]
Gaggini, M.; Morelli, M.; Buzzigoli, E.; DeFronzo, R.A.; Bugianesi, E.; Gastaldelli, A. Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease. Nutrients, 2013, 5(5), 1544-1560.
[http://dx.doi.org/10.3390/nu5051544] [PMID: 23666091]
[3]
Stanley, W.C.; Recchia, F.A. Lipotoxicity and the development of heart failure: moving from mouse to man. Cell Metab., 2010, 12(6), 555-556.
[http://dx.doi.org/10.1016/j.cmet.2010.11.016] [PMID: 21109186]
[4]
Mozaffarian, D. Foods, obesity, and diabetes-are all calories created equal? Nutr. Rev., 2017, 75(Suppl. 1), 19-31.
[http://dx.doi.org/10.1093/nutrit/nuw024] [PMID: 28049747]
[5]
Lim, S.; Vos, T.; Flaxman, A. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet, 2012, 380(9859), 2224-2260.
[http://dx.doi.org/10.1016/S0140-6736(12)61766-8] [PMID: 23245609]
[6]
Murray, C.J.; Atkinson, C.; Bhalla, K.; Birbeck, G.; Burstein, R.; Chou, D.; Dellavalle, R.; Danaei, G.; Ezzati, M.; Fahimi, A.; Flaxman, D. Foreman; Gabriel, S.; Gakidou, E.; Kassebaum, N.; Khatibzadeh, S.; Lim, S.; Lipshultz, S.E.; London, S.; Lopez; MacIntyre, M.F.; Mokdad, A.H.; Moran, A.; Moran, A.E.; Mozaffarian, D.; Murphy, T.; Naghavi, M.; Pope, C.; Roberts, T.; Salomon, J.; Schwebel, D.C.; Shahraz, S.; Sleet, D.A.; Murray; Abraham, J.; Ali, M.K.; Atkinson, C.; Bartels, D.H.; Bhalla, K.; Birbeck, G.; Burstein, R.; Chen, H.; Criqui, M.H.; Dahodwala; Jarlais; Ding, E.L.; Dorsey, E.R.; Ebel, B.E.; Ezzati, M.; Fahami; Flaxman, S.; Flaxman, A.D.; Gonzalez-Medina, D.; Grant, B.; Hagan, H.; Hoffman, H.; Kassebaum, N.; Khatibzadeh, S.; Leasher, J.L.; Lin, J.; Lipshultz, S.E.; Lozano, R.; Lu, Y.; Mallinger, L.; McDermott, M.M.; Micha, R.; Miller, T.R.; Mokdad, A.A.; Mokdad, A.H.; Mozaffarian, D.; Naghavi, M.; Narayan, K.M.; Omer, S.B.; Pelizzari, P.M.; Phillips, D.; Ranganathan, D.; Rivara, F.P.; Roberts, T.; Sampson, U.; Sanman, E.; Sapkota, A.; Schwebel, D.C.; Sharaz, S.; Shivakoti, R.; Singh, G.M.; Singh, D.; Tavakkoli, M.; Towbin, J.A.; Wilkinson, J.D.; Zabetian, A.; Murray; Abraham, J.; Ali, M.K.; Alvardo, M.; Atkinson, C.; Baddour, L.M.; Benjamin, E.J.; Bhalla, K.; Birbeck, G.; Bolliger, I.; Burstein, R.; Carnahan, E.; Chou, D.; Chugh, S.S.; Cohen, A.; Colson, K.E.; Cooper, L.T.; Couser, W.; Criqui, M.H.; Dabhadkar, K.C.; Dellavalle, R.P.; Jarlais; Dicker, D.; Dorsey, E.R.; Duber, H.; Ebel, B.E.; Engell, R.E.; Ezzati, M.; Felson, D.T.; Finucane, M.M.; Flaxman, S.; Flaxman, A.D.; Fleming, T.; Foreman; Forouzanfar, M.H.; Freedman, G.; Freeman, M.K.; Gakidou, E.; Gillum, R.F.; Gonzalez-Medina, D.; Gosselin, R.; Gutierrez, H.R.; Hagan, H.; Havmoeller, R.; Hoffman, H.; Jacobsen, K.H.; James, S.L.; Jasrasaria, R.; Jayarman, S.; Johns, N.; Kassebaum, N.; Khatibzadeh, S.; Lan, Q.; Leasher, J.L.; Lim, S.; Lipshultz, S.E.; London, S.; Lopez; Lozano, R.; Lu, Y.; Mallinger, L.; Meltzer, M.; Mensah, G.A.; Michaud, C.; Miller, T.R.; Mock, C.; Moffitt, T.E.; Mokdad, A.A.; Mokdad, A.H.; Moran, A.; Naghavi, M.; Narayan, K.M.; Nelson, R.G.; Olives, C.; Omer, S.B.; Ortblad, K.; Ostro, B.; Pelizzari, P.M.; Phillips, D.; Raju, M.; Razavi, H.; Ritz, B.; Roberts, T.; Sacco, R.L.; Salomon, J.; Sampson, U.; Schwebel, D.C.; Shahraz, S.; Shibuya, K.; Silberberg, D.; Singh, J.A.; Steenland, K.; Taylor, J.A.; Thurston, G.D.; Vavilala, M.S.; Vos, T.; Wagner, G.R.; Weinstock, M.A.; Weisskopf, M.G.; Wulf, S.; Murray, U.S. Burden of Disease Collaborators. The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA, 2013, 310(6), 591-608.
[http://dx.doi.org/10.1001/jama.2013.13805] [PMID: 23842577]
[7]
Mozaffarian, D.; Wilson, P.W.; Kannel, W.B. Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease. Circulation, 2008, 117(23), 3031-3038.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.107.738732] [PMID: 18541753]
[8]
Meule, A.; Gearhardt, A.N. Food addiction in the light of DSM-5. Nutrients, 2014, 6(9), 3653-3671.
[http://dx.doi.org/10.3390/nu6093653] [PMID: 25230209]
[9]
Gearhardt, A.N.; Grilo, C.M.; DiLeone, R.J.; Brownell, K.D.; Potenza, M.N. Can food be addictive? Public health and policy implications. Addiction, 2011, 106(7), 1208-1212.
[http://dx.doi.org/10.1111/j.1360-0443.2010.03301.x] [PMID: 21635588]
[10]
De Lorenzo, A.; Noce, A.; Moriconi, E.; Rampello, T.; Marrone, G.; Di Daniele, N.; Rovella, V. MOSH Syndrome (male obesity secondary hypogonadism): clinical assessment and possible therapeutic approaches. Nutrients, 2018, 10(4), E474
[http://dx.doi.org/10.3390/nu10040474] [PMID: 29649106]
[11]
Rizzo, M.; Tyndall, E.K.; Frontoni, S.; Jacoangeli, F.; Sarlo, F.; Panebianco, F.; Mistorni, A.; Di Renzo, L.; Calafiore, R.; Luca, G.; De Lorenzo, A. Rapid and easy assessment of insulin resistance contributes to early detection of polycystic ovary syndrome. J. Endocrinol. Invest., 2013, 36(7), 527-530.
[PMID: 23612476]
[12]
Bruno, E.; Alessandrini, M.; Napolitano, B.; De Padova, A.; Di Daniele, N.; De Lorenzo, A. Dual-energy X-ray absorptiometry analysis of body composition in patients affected by OSAS. Eur. Arch. Otorhinolaryngol., 2009, 266(8), 1285-1290.
[http://dx.doi.org/10.1007/s00405-008-0844-0] [PMID: 18982339]
[13]
Mozaffarian, D. Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review. Circulation, 2016, 133(2), 187-225.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.115.018585] [PMID: 26746178]
[14]
Baker, K.D.; Loughman, A.; Spencer, S.J.; Reichelt, A.C. The impact of obesity and hypercaloric diet consumption on anxiety and emotional behavior across the lifespan. Neurosci. Biobehav. Rev., 2017, 83, 173-182.
[http://dx.doi.org/10.1016/j.neubiorev.2017.10.014] [PMID: 29054731]
[15]
Aguilar-Valles, A; Inoue, W; Rummel, C; Luheshi, G.N. Obesity, adipokines and neuroinflammation. Neuropharmacology, 2015, 96(Pt A), 124-34.
[http://dx.doi.org/10.1016/j.neuropharm.2014.12.023] [PMID: 25582291]
[16]
Bloom, D.E.; Cafiero, E.T.; Jané-Llopis, E. The global economic burden of noncommunicable diseases. World Economic Forum 2011.
[17]
Micha, R.; Shulkin, M.L.; Peñalvo, J.L.; Khatibzadeh, S.; Singh, G.M.; Rao, M.; Fahimi, S.; Powles, J.; Mozaffarian, D. Etiologic effects and optimal intakes of foods and nutrients for risk of cardiovascular diseases and diabetes: Systematic reviews and meta-analyses from the Nutrition and Chronic Diseases Expert Group (NutriCoDE). PLoS One, 2017, 12(4), e0175149
[http://dx.doi.org/10.1371/journal.pone.0175149] [PMID: 28448503]
[18]
Carter, A.; Hendrikse, J.; Lee, N.; Yücel, M.; Verdejo-Garcia, A.; Andrews, Z.B.; Hall, W. The neurobiology of “Food Addiction” and its implications for obesity treatment and policy. Annu. Rev. Nutr., 2016, 36, 105-128.
[http://dx.doi.org/10.1146/annurev-nutr-071715-050909] [PMID: 27296500]
[19]
Bray, G.A.; Kim, K.K.; Wilding, J.P.H. World Obesity Federation. Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obes. Rev., 2017, 18(7), 715-723.
[http://dx.doi.org/10.1111/obr.12551] [PMID: 28489290]
[20]
Bray, G.A.; Champagne, C.M. Beyond energy balance: there is more to obesity than kilocalories. J. Am. Diet. Assoc., 2005, 105(5)(Suppl. 1), S17-S23.
[http://dx.doi.org/10.1016/j.jada.2005.02.018] [PMID: 15867891]
[21]
American Medical Association. Council on Science and Public Health Report, 2013.
[22]
Li, C.; Ford, E.S.; Zhao, G.; Balluz, L.S.; Giles, W.H. Estimates of body composition with dual-energy X-ray absorptiometry in adults. Am. J. Clin. Nutr., 2009, 90(6), 1457-1465.
[http://dx.doi.org/10.3945/ajcn.2009.28141] [PMID: 19812179]
[23]
Gómez-Ambrosi, J.; Silva, C.; Galofré, J.C.; Escalada, J.; Santos, S.; Millán, D.; Vila, N.; Ibañez, P.; Gil, M.J.; Valentí, V.; Rotellar, F.; Ramírez, B.; Salvador, J.; Frühbeck, G. Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int. J. Obes., 2012, 36(2), 286-294.
[http://dx.doi.org/10.1038/ijo.2011.100] [PMID: 21587201]
[24]
Sun, Q.; van Dam, R.M.; Spiegelman, D.; Heymsfield, S.B.; Willett, W.C.; Hu, F.B. Comparison of dual-energy x-ray absorptiometric and anthropometric measures of adiposity in relation to adiposity-related biologic factors. Am. J. Epidemiol., 2010, 172(12), 1442-1454.
[http://dx.doi.org/10.1093/aje/kwq306] [PMID: 20952596]
[25]
Di Angelantonio, E.; Bhupathiraju, ShN.; Wormser, D.; Gao, P.; Kaptoge, S.; Berrington de Gonzalez, A.; Cairns, B.J.; Huxley, R.; Jackson, ChL.; Joshy, G.; Lewington, S.; Manson, J.E.; Murphy, N.; Patel, A.V.; Samet, J.M.; Woodward, M.; Zheng, W.; Zhou, M.; Bansal, N.; Barricarte, A.; Carter, B.; Cerhan, J.R.; Smith, G.D.; Fang, X.; Franco, O.H.; Green, J.; Halsey, J.; Hildebrand, J.S.; Jung, K.J.; Korda, R.J.; McLerran, D.F.; Moore, S.C.; O’Keeffe, L.M.; Paige, E.; Ramond, A.; Reeves, G.K.; Rolland, B.; Sacerdote, C.; Sattar, N.; Sofianopoulou, E.; Stevens, J.; Thun, M.; Ueshima, H.; Yang, L.; Yun, Y.D.; Willeit, P.; Banks, E.; Beral, V.; Chen, Zh.; Gapstur, S.M.; Gunter, M.J.; Hartge, P.; Jee, S.H.; Lam, T.H.; Peto, R.; Potter, J.D.; Willett, W.C.; Thompson, S.G.; Danesh, J.; Hu, F.B. Global BMI Mortality Collaboration. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet, 2016, 388(10046), 776-786.
[http://dx.doi.org/10.1016/S0140-6736(16)30175-1] [PMID: 27423262]
[26]
Snitker, S. Use of body fatness cutoff points. Mayo Clin. Proc., 2010, 85(11), 1057.
[http://dx.doi.org/10.4065/mcp.2010.0583] [PMID: 21037049]
[27]
De Lorenzo, A.; Bianchi, A.; Maroni, P.; Iannarelli, A.; Di Daniele, N.; Iacopino, L.; Di Renzo, L. Adiposity rather than BMI determines metabolic risk. Int. J. Cardiol., 2013, 166(1), 111-117.
[http://dx.doi.org/10.1016/j.ijcard.2011.10.006] [PMID: 22088224]
[28]
Biddle, S.J.; García Bengoechea, E.; Wiesner, G. Sedentary behaviour and adiposity in youth: a systematic review of reviews and analysis of causality. Int. J. Behav. Nutr. Phys. Act., 2017, 14(1), 43.
[http://dx.doi.org/10.1186/s12966-017-0497-8] [PMID: 28351363]
[29]
De Lorenzo, A.; Martinoli, R.; Vaia, F.; Di Renzo, L. Normal weight obese (NWO) women: an evaluation of a candidate new syndrome. Nutr. Metab. Cardiovasc. Dis., 2006, 16(8), 513-523.
[http://dx.doi.org/10.1016/j.numecd.2005.10.010] [PMID: 17126766]
[30]
Karelis, A.D.; St-Pierre, D.H.; Conus, F.; Rabasa-Lhoret, R.; Poehlman, E.T. Metabolic and body composition factors in subgroups of obesity: what do we know? J. Clin. Endocrinol. Metab., 2004, 89(6), 2569-2575.
[http://dx.doi.org/10.1210/jc.2004-0165] [PMID: 15181025]
[31]
Seo, M.H.; Rhee, E.J. Metabolic and cardiovascular implications of a metabolically healthy obesity phenotype. Endocrinol. Metab. (Seoul), 2014, 29(4), 427-434.
[http://dx.doi.org/10.3803/EnM.2014.29.4.427] [PMID: 25559571]
[32]
De Lorenzo, A.; Del Gobbo, V.; Premrov, M.G.; Bigioni, M.; Galvano, F.; Di Renzo, L. Normal-weight obese syndrome: early inflammation? Am. J. Clin. Nutr., 2007, 85(1), 40-45.
[http://dx.doi.org/10.1093/ajcn/85.1.40] [PMID: 17209175]
[33]
Marques-Vidal, P.; Pécoud, A.; Hayoz, D.; Paccaud, F.; Mooser, V.; Waeber, G.; Vollenweider, P. Normal weight obesity: relationship with lipids, glycaemic status, liver enzymes and inflammation. Nutr. Metab. Cardiovasc. Dis., 2010, 20(9), 669-675.
[http://dx.doi.org/10.1016/j.numecd.2009.06.001] [PMID: 19748248]
[34]
Di Renzo, L.; Del Gobbo, V.; Bigioni, M.; Premrov, M.G.; Cianci, R.; De Lorenzo, A. Body composition analyses in normal weight obese women. Eur. Rev. Med. Pharmacol. Sci., 2006, 10(4), 191-196.
[PMID: 16910350]
[35]
Marques-Vidal, P.; Chiolero, A.; Paccaud, F. Large differences in the prevalence of normal weight obesity using various cut-offs for excess body fat. E Spen Eur. E J. Clin. Nutr. Metab., 2008, 3, e159-e162.
[http://dx.doi.org/10.1016/j.eclnm.2008.05.003]
[36]
Madeira, F.B.; Silva, A.A.; Veloso, H.F.; Goldani, M.Z.; Kac, G.; Cardoso, V.C.; Bettiol, H.; Barbieri, M.A. Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country. PLoS One, 2013, 8(3), e60673
[http://dx.doi.org/10.1371/journal.pone.0060673] [PMID: 23556000]
[37]
Di Renzo, L.; Galvano, F.; Orlandi, C.; Bianchi, A.; Di Giacomo, C.; La Fauci, L.; Acquaviva, R.; De Lorenzo, A. Oxidative stress in normal-weight obese syndrome. Obesity (Silver Spring), 2010, 18(11), 2125-2130.
[http://dx.doi.org/10.1038/oby.2010.50] [PMID: 20339360]
[38]
Kim, J.Y.; Han, S.H.; Yang, B.M. Implication of high-body-fat percentage on cardiometabolic risk in middle-aged, healthy, normal-weight adults. Obesity (Silver Spring), 2013, 21(8), 1571-1577.
[http://dx.doi.org/10.1002/oby.20020] [PMID: 23404833]
[39]
Dvorak, R.V.; DeNino, W.F.; Ades, P.A.; Poehlman, E.T. Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women. Diabetes, 1999, 48(11), 2210-2214.
[http://dx.doi.org/10.2337/diabetes.48.11.2210] [PMID: 10535456]
[40]
Succurro, E.; Marini, M.A.; Frontoni, S.; Hribal, M.L.; Andreozzi, F.; Lauro, R.; Perticone, F.; Sesti, G. Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals. Obesity (Silver Spring), 2008, 16(8), 1881-1886.
[http://dx.doi.org/10.1038/oby.2008.308] [PMID: 18551117]
[41]
Thomas, E.L.; Frost, G.; Taylor-Robinson, S.D.; Bell, J.D. Excess body fat in obese and normal-weight subjects. Nutr. Res. Rev., 2012, 25(1), 150-161.
[http://dx.doi.org/10.1017/S0954422412000054] [PMID: 22625426]
[42]
Esposito, K.; Giugliano, D. The metabolic syndrome and inflammation: association or causation? Nutr. Metab. Cardiovasc. Dis., 2004, 14(5), 228-232.
[http://dx.doi.org/10.1016/S0939-4753(04)80048-6] [PMID: 15673055]
[43]
Bonora, E.; Willeit, J.; Kiechl, S.; Oberhollenzer, F.; Egger, G.; Bonadonna, R.; Muggeo, M. U-shaped and J-shaped relationships between serum insulin and coronary heart disease in the general population. The Bruneck Study. Diabetes Care, 1998, 21(2), 221-230.
[http://dx.doi.org/10.2337/diacare.21.2.221] [PMID: 9539986]
[44]
Sims, E.A. Are there persons who are obese, but metabolically healthy? Metabolism, 2001, 50(12), 1499-1504.
[http://dx.doi.org/10.1053/meta.2001.27213] [PMID: 11735101]
[45]
Cho, Y.K.; Kang, Y.M.; Yoo, J.H.; Lee, J.; Park, J.Y.; Lee, W.J.; Kim, Y.J.; Jung, C.H. Implications of the dynamic nature of metabolic health status and obesity on risk of incident cardiovascular events and mortality: a nationwide population-based cohort study. Metabolism, 2019, 97, 50-56.
[http://dx.doi.org/10.1016/j.metabol.2019.05.002] [PMID: 31071310]
[46]
Arnlöv, J.; Ingelsson, E.; Sundström, J.; Lind, L. Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation, 2010, 121(2), 230-236.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.109.887521] [PMID: 20038741]
[47]
Flint, A.J.; Hu, F.B.; Glynn, R.J.; Caspard, H.; Manson, J.E.; Willett, W.C.; Rimm, E.B. Excess weight and the risk of incident coronary heart disease among men and women. Obesity (Silver Spring), 2010, 18(2), 377-383.
[http://dx.doi.org/10.1038/oby.2009.223] [PMID: 19629058]
[48]
Eshtiaghi, R.; Keihani, S.; Hosseinpanah, F.; Barzin, M.; Azizi, F. Natural course of metabolically healthy abdominal obese adults after 10 years of follow-up: the Tehran Lipid and Glucose Study. Int. J. Obes., 2015, 39(3), 514-519.
[http://dx.doi.org/10.1038/ijo.2014.176] [PMID: 25287753]
[49]
Puri, R. Is it finally time to dispel the concept of metabolically-healthy obesity? J. Am. Coll. Cardiol., 2014, 63(24), 2687-2688.
[http://dx.doi.org/10.1016/j.jacc.2014.03.043] [PMID: 24794116]
[50]
Després, J.P. Body fat distribution and risk of cardiovascular disease: an update. Circulation, 2012, 126(10), 1301-1313.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.111.067264] [PMID: 22949540]
[51]
Timmers, S.; Konings, E.; Bilet, L.; Houtkooper, R.H.; van de Weijer, T.; Goossens, G.H.; Hoeks, J.; van der Krieken, S.; Ryu, D.; Kersten, S.; Moonen-Kornips, E.; Hesselink, M.K.C.; Kunz, I.; Schrauwen-Hinderling, V.B.; Blaak, E.; Auwerx, J.; Schrauwen, P. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab., 2011, 14(5), 612-622.
[http://dx.doi.org/10.1016/j.cmet.2011.10.002] [PMID: 22055504]
[52]
Alberti, K.G.; Zimmet, P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med., 1998, 15(7), 539-553.
[http://dx.doi.org/10.1002/(SICI)1096-9136(199807)15:7<539:AID-DIA668>3.0.CO;2-S] [PMID: 9686693]
[53]
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA, 2001, 285(19), 2486-2497.
[http://dx.doi.org/10.1001/jama.285.19.2486] [PMID: 11368702]
[54]
Keys, A.; Menotti, A.; Karvonen, M.J.; Aravanis, C.; Blackburn, H.; Buzina, R.; Djordjevic, B.S.; Dontas, A.S.; Fidanza, F.; Keys, M.H. The diet and 15-year death rate in the seven countries study. Am. J. Epidemiol., 1986, 124(6), 903-915.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a114480] [PMID: 3776973]
[55]
Wycherley, T.P.; Brinkworth, G.D.; Clifton, P.M.; Noakes, M. Comparison of the effects of 52 weeks weight loss with either a high-protein or high-carbohydrate diet on body composition and cardiometabolic risk factors in overweight and obese males. Nutr. Diabetes, 2012, 2(8), e40
[http://dx.doi.org/10.1038/nutd.2012.11] [PMID: 23448804]
[56]
Ilich, J.Z.; Kelly, O.J.; Inglis, J.E. Osteosarcopenic obesity syndrome: what is it and how can it be identified and diagnosed? Curr. Gerontol. Geriatr. Res., 2016, 2016, 7325973
[http://dx.doi.org/10.1155/2016/7325973] [PMID: 27667996]
[57]
Hill, K.D.; Farrier, K.; Russell, M.; Burton, E. Dysmobility syndrome: current perspectives. Clin. Interv. Aging, 2017, 12, 145-152.
[http://dx.doi.org/10.2147/CIA.S102961] [PMID: 28144132]
[58]
Egger, G. In search of a germ theory equivalent for chronic disease. Prev. Chronic Dis., 2012, 9, e95
[http://dx.doi.org/10.5888/pcd9.110301] [PMID: 22575080]
[59]
Viswanath, V.; Danda, D. Inflammation, metabolism and adipokines: toward a unified theory. Int. J. Rheum. Dis., 2016, 19(7), 633-636.
[http://dx.doi.org/10.1111/1756-185X.12958] [PMID: 27538673]
[60]
Harris, B. Public health, nutrition and the decline of mortality: the McKeown thesis revisited.. Soc. Hist. Med., 2004.17(3), 379-407.
[http://dx.doi.org/10.1093/shm/17.3.379]
[61]
Di Daniele, N.; Noce, A.; Vidiri, M.F.; Moriconi, E.; Marrone, G.; Annicchiarico-Petruzzelli, M.; D’Urso, G.; Tesauro, M.; Rovella, V.; De Lorenzo, A. Impact of Mediterranean diet on metabolic syndrome, cancer and longevity. Oncotarget, 2017, 8(5), 8947-8979.
[http://dx.doi.org/10.18632/oncotarget.13553] [PMID: 27894098]
[62]
Di Daniele, N.; Condò, S.; Ferrannini, M.; Bertoli, M.; Rovella, V.; Di Renzo, L.; De Lorenzo, A. Brown tumour in a patient with secondary hyperparathyroidism resistant to medical therapy: case report on successful treatment after subtotal parathyroidectomy. Int. J. Endocrinol., 2009, 2009, 827652
[http://dx.doi.org/10.1155/2009/827652] [PMID: 20011058]
[63]
Abenavoli, L.; Luigiano, C.; Guzzi, P.H.; Milic, N.; Morace, C.; Stelitano, L.; Consolo, P.; Miraglia, S.; Fagoonee, S.; Virgilio, C.; Luzza, F.; De Lorenzo, A.; Pellicano, R. Serum adipokine levels in overweight patients and their relationship with non-alcoholic fatty liver disease. Panminerva Med., 2014, 56(2), 189-193.
[PMID: 24994581]
[64]
Koster, A.; Stenholm, S.; Alley, D.E.; Kim, L.J.; Simonsick, E.M.; Kanaya, A.M.; Visser, M.; Houston, D.K.; Nicklas, B.J.; Tylavsky, F.A.; Satterfield, S.; Goodpaster, B.H.; Ferrucci, L.; Harris, T.B. Health ABC study. Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity (Silver Spring), 2010, 18(12), 2354-2361.
[http://dx.doi.org/10.1038/oby.2010.86] [PMID: 20395951]
[65]
Di Renzo, L.; Bianchi, A.; Saraceno, R.; Calabrese, V.; Cornelius, C.; Iacopino, L.; Chimenti, S.; De Lorenzo, A. -174G/C IL-6 gene promoter polymorphism predicts therapeutic response to TNF-α blockers. Pharmacogenet. Genomics, 2012, 22(2), 134-142.
[http://dx.doi.org/10.1097/FPC.0b013e32834e5e7b] [PMID: 22158445]
[66]
Di Renzo, L.; Di Pierro, D.; Bigioni, M.; Sodi, V.; Galvano, F.; Cianci, R.; La Fauci, L.; De Lorenzo, A. Is antioxidant plasma status in humans a consequence of the antioxidant food content influence? Eur. Rev. Med. Pharmacol. Sci., 2007, 11(3), 185-192.
[PMID: 17970235]
[67]
Hill, J.O.; Wyatt, H.R.; Reed, G.W.; Peters, J.C. Obesity and the environment: where do we go from here? Science, 2003, 299(5608), 853-855.
[http://dx.doi.org/10.1126/science.1079857] [PMID: 12574618]
[68]
Sladoje, D.P.; Kisić, B.; Mirić, D. The monitoring of protein markers of inflammation and serum lipid concentration in obese subjects with metabolic syndrome. J. Med. Biochem., 2017, 36(4), 366-374.
[http://dx.doi.org/10.1515/jomb-2017-0009] [PMID: 30581334]
[69]
Di Renzo, L.; Bertoli, A.; Bigioni, M.; Del Gobbo, V.; Premrov, M.G.; Calabrese, V.; Di Daniele, N.; De Lorenzo, A. Body composition and -174G/C interleukin-6 promoter gene polymorphism: association with progression of insulin resistance in normal weight obese syndrome. Curr. Pharm. Des., 2008, 14(26), 2699-2706.
[http://dx.doi.org/10.2174/138161208786264061] [PMID: 18991689]
[70]
Amani, R.; Parohan, M.; Jomehzadeh, N.; Haghighizadeh, M.H. Dietary and biochemical characteristics associated with normal-weight obesity. Int. J. Vitam. Nutr. Res., 2019, 89(5-6), 331-336.
[http://dx.doi.org/10.1024/0300-9831/a000477] [PMID: 30856081]
[71]
Henrichot, E.; Juge-Aubry, C.E.; Pernin, A.; Pache, J.C.; Velebit, V.; Dayer, J.M.; Meda, P.; Chizzolini, C.; Meier, C.A. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Arterioscler. Thromb. Vasc. Biol., 2005, 25(12), 2594-2599.
[http://dx.doi.org/10.1161/01.ATV.0000188508.40052.35] [PMID: 16195477]
[72]
Love, A.; Oldford, D. Metabolic syndrome. Can. J. Cardiovasc. Nurs., 2005, 15(2), 6-8.
[PMID: 15973860]
[73]
Baquero, F.; Nombela, C. The microbiome as a human organ. Clin. Microbiol. Infect., 2012, 18(Suppl. 4), 2-4.
[http://dx.doi.org/10.1111/j.1469-0691.2012.03916.x] [PMID: 22647038]
[74]
Sirisinha, S. The potential impact of gut microbiota on your health:Current status and future challenges. Asian Pac. J. Allergy Immunol., 2016, 34(4), 249-264.
[PMID: 28042926]
[75]
Cani, P.D.; Possemiers, S.; Van de Wiele, T.; Guiot, Y.; Everard, A.; Rottier, O.; Geurts, L.; Naslain, D.; Neyrinck, A.; Lambert, D.M.; Muccioli, G.G.; Delzenne, N.M. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut, 2009, 58(8), 1091-1103.
[http://dx.doi.org/10.1136/gut.2008.165886] [PMID: 19240062]
[76]
Koliada, A.; Syzenko, G.; Moseiko, V.; Budovska, L.; Puchkov, K.; Perederiy, V.; Gavalko, Y.; Dorofeyev, A.; Romanenko, M.; Tkach, S.; Sineok, L.; Lushchak, O.; Vaiserman, A. Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population. BMC Microbiol., 2017, 17(1), 120.
[http://dx.doi.org/10.1186/s12866-017-1027-1] [PMID: 28532414]
[77]
de La Serre, C.B.; Ellis, C.L.; Lee, J.; Hartman, A.L.; Rutledge, J.C.; Raybould, H.E. Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am. J. Physiol. Gastrointest. Liver Physiol., 2010, 299(2), G440-G448.
[http://dx.doi.org/10.1152/ajpgi.00098.2010] [PMID: 20508158]
[78]
Ridaura, V.; Belkaid, Y. Gut microbiota: the link to your second brain. Cell, 2015, 161(2), 193-194.
[http://dx.doi.org/10.1016/j.cell.2015.03.033] [PMID: 25860600]
[79]
Avolio, E.; Fazzari, G.; Zizza, M.; De Lorenzo, A.; Di Renzo, L.; Alò, R.; Facciolo, R.M.; Canonaco, M. Probiotics modify body weight together with anxiety states via pro-inflammatory factors in HFD-treated Syrian golden hamster. Behav. Brain Res., 2019, 356, 390-399.
[http://dx.doi.org/10.1016/j.bbr.2018.09.010] [PMID: 30223002]
[80]
Colica, C.; Avolio, E.; Bollero, P.; Costa de Miranda, R.; Ferraro, S.; Sinibaldi Salimei, P.; De Lorenzo, A.; Di Renzo, L. Evidences of a new psychobiotic formulation on body composition and anxiety. Mediators Inflamm., 2017, 2017, 5650627
[http://dx.doi.org/10.1155/2017/5650627] [PMID: 29147070]
[81]
De Lorenzo, A.; Costacurta, M.; Merra, G.; Gualtieri, P.; Cioccoloni, G.; Marchetti, M.; Varvaras, D.; Docimo, R.; Di Renzo, L. Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial. J. Transl. Med., 2017, 15(1), 135.
[http://dx.doi.org/10.1186/s12967-017-1236-2] [PMID: 28601084]
[82]
De Lorenzo, A.; Soldati, L.; Sarlo, F.; Calvani, M.; Di Lorenzo, N.; Di Renzo, L. New obesity classification criteria as a tool for bariatric surgery indication. World J. Gastroenterol., 2016, 22(2), 681-703.
[http://dx.doi.org/10.3748/wjg.v22.i2.681] [PMID: 26811617]
[83]
Martin, KA; Mani, MV; Mani, A New targets to treat obesity and the metabolic syndrome. Eur J Pharmacol, 2015, 763(Pt A), 64-74.
[http://dx.doi.org/10.1016/j.ejphar.2015.03.093]
[84]
Salamone, D.; Muresan, S.; Muresan, M.; Neagoe, R. Multilevel brown tumors of the spine in a patient with severe secondary hyperparathyroidism A case report and review of the literature. Ann. Ital. Chir, 2016, 87(ePub), 87.
[PMID: 27064191]
[85]
Andreoli, A.; De Lorenzo, A.; Cadeddu, F.; Iacopino, L.; Grande, M. New trends in nutritional status assessment of cancer patients. Eur. Rev. Med. Pharmacol. Sci., 2011, 15(5), 469-480.
[PMID: 21744742]
[86]
Hall, J.E. The kidney, hypertension, and obesity. Hypertension, 2003, 41(3 Pt 2), 625-633.
[PMID: 12623970]
[87]
Hall, J.E.; Brands, M.W.; Dixon, W.N.; Smith, M.J. Jr. Obesity-induced hypertension. Renal function and systemic hemodynamics. Hypertension, 1993, 22(3), 292-299.
[http://dx.doi.org/10.1161/01.HYP.22.3.292] [PMID: 8349321]
[88]
Messerli, F.H.; Christie, B.; DeCarvalho, J.G.; Aristimuno, G.G.; Suarez, D.H.; Dreslinski, G.R.; Frohlich, E.D. Obesity and essential hypertension. Hemodynamics, intravascular volume, sodium excretion, and plasma renin activity. Arch. Intern. Med., 1981, 141(1), 81-85.
[http://dx.doi.org/10.1001/archinte.1981.00340010073016] [PMID: 7004372]
[89]
Kotsis, V.; Stabouli, S.; Bouldin, M.; Low, A.; Toumanidis, S.; Zakopoulos, N. Impact of obesity on 24-hour ambulatory blood pressure and hypertension. Hypertension, 2005, 45(4), 602-607.
[http://dx.doi.org/10.1161/01.HYP.0000158261.86674.8e] [PMID: 15723966]
[90]
Arnold, M.; Pandeya, N.; Byrnes, G.; Renehan, P.A.G.; Stevens, G.A.; Ezzati, P.M.; Ferlay, J.; Miranda, J.J.; Romieu, I.; Dikshit, R.; Forman, D.; Soerjomataram, I. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol., 2015, 16(1), 36-46.
[http://dx.doi.org/10.1016/S1470-2045(14)71123-4] [PMID: 25467404]
[91]
Lashinger, L.M.; Ford, N.A.; Hursting, S.D. Interacting inflammatory and growth factor signals underlie the obesity-cancer link. J. Nutr., 2014, 144(2), 109-113.
[http://dx.doi.org/10.3945/jn.113.178533] [PMID: 24285690]
[92]
Munsell, M.F.; Sprague, B.L.; Berry, D.A.; Chisholm, G.; Trentham-Dietz, A. Body mass index and breast cancer risk according to postmenopausal estrogen-progestin use and hormone receptor status. Epidemiol. Rev., 2014, 36, 114-136.
[http://dx.doi.org/10.1093/epirev/mxt010] [PMID: 24375928]
[93]
Lu, C.W.; Lo, Y.H.; Chen, C.H.; Lin, C.Y.; Tsai, C.H.; Chen, P.J.; Yang, Y.F.; Wang, C.H.; Tan, C.H.; Hou, M.F.; Yuan, S.F. VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis. Cancer Lett., 2017, 388, 130-138.
[http://dx.doi.org/10.1016/j.canlet.2016.11.033] [PMID: 27940127]
[94]
Christopoulos, P.F.; Msaouel, P.; Koutsilieris, M. The role of the insulin-like growth factor-1 system in breast cancer. Mol. Cancer, 2015, 14, 43.
[http://dx.doi.org/10.1186/s12943-015-0291-7] [PMID: 25743390]
[95]
Azvolinsky, A. Cancer risk: the fat tissue-BMI-obesity connection. J. Natl. Cancer Inst., 2014, 106(4), dju100
[http://dx.doi.org/10.1093/jnci/dju100] [PMID: 24685924]
[96]
Mason, J.K.; Thompson, L.U. Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer? Appl. Physiol. Nutr. Metab., 2014, 39(6), 663-678.
[http://dx.doi.org/10.1139/apnm-2013-0420] [PMID: 24869971]
[97]
Hu, M.B.; Liu, S.H.; Jiang, H.W.; Bai, P.D.; Ding, Q. Obesity affects the biopsy-mediated detection of prostate cancer, particularly high-grade prostate cancer: a dose-response meta-analysis of 29,464 patients. PLoS One, 2014, 9(9), e106677
[http://dx.doi.org/10.1371/journal.pone.0106677] [PMID: 25184215]
[98]
Bañez, L.L.; Hamilton, R.J.; Partin, A.W.; Vollmer, R.T.; Sun, L.; Rodriguez, C.; Wang, Y.; Terris, M.K.; Aronson, W.J.; Presti, J.C., Jr; Kane, C.J.; Amling, C.L.; Moul, J.W.; Freedland, S.J. Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer. JAMA, 2007, 298(19), 2275-2280.
[http://dx.doi.org/10.1001/jama.298.19.2275] [PMID: 18029831]
[99]
Whiting, D.R.; Guariguata, L.; Weil, C.; Shaw, J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res. Clin. Pract., 2011, 94(3), 311-321.
[http://dx.doi.org/10.1016/j.diabres.2011.10.029] [PMID: 22079683]
[100]
Steven, S.; Hollingsworth, K.G.; Al-Mrabeh, A.; Avery, L.; Aribisala, B.; Caslake, M.; Taylor, R. Very low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders. Diabetes Care, 2016, 39(5), 808-815.
[http://dx.doi.org/10.2337/dc15-1942] [PMID: 27002059]
[101]
Qiao, Q.; Nyamdorj, R. Is the association of type II diabetes with waist circumference or waist-to-hip ratio stronger than that with body mass index? Eur. J. Clin. Nutr., 2010, 64(1), 30-34.
[http://dx.doi.org/10.1038/ejcn.2009.93] [PMID: 19724291]
[102]
Svendsen, O.L.; Hassager, C. Body composition and fat distribution measured by dual-energy x-ray absorptiometry in premenopausal and postmenopausal insulin-dependent and non-insulin-dependent diabetes mellitus patients. Metabolism, 1998, 47(2), 212-216.
[http://dx.doi.org/10.1016/S0026-0495(98)90223-2] [PMID: 9472973]
[103]
Song, X.M.; Ryder, J.W.; Kawano, Y.; Chibalin, A.V.; Krook, A.; Zierath, J.R. Muscle fiber type specificity in insulin signal transduction. Am. J. Physiol., 1999, 277(6), R1690-R1696.
[PMID: 10600915]
[104]
Magkos, F.; Wang, X.; Mittendorfer, B. Metabolic actions of insulin in men and women. Nutrition, 2010, 26(7-8), 686-693.
[http://dx.doi.org/10.1016/j.nut.2009.10.013] [PMID: 20392600]
[105]
Di Renzo, L.; Cammarano, A.; De Lorenzo, A. The missclassification of obesity affects the course of migraine. J. Headache Pain, 2018, 19(1), 63.
[http://dx.doi.org/10.1186/s10194-018-0895-6] [PMID: 30076482]
[106]
De Lorenzo, A.; Di Renzo, L.; Morini, P.; de Miranda, R.C.; Romano, L.; Colica, C. New equations to estimate resting energy expenditure in obese adults from body composition. Acta Diabetol., 2018, 55(1), 59-66.
[http://dx.doi.org/10.1007/s00592-017-1061-3] [PMID: 29086030]
[107]
Cirulli, E.T.; Guo, L.; Leon Swisher, C. Profound perturbation of the metabolome in obesity is associated with health risk. Cell Metab., 2018, S1550, 30630-30632.
[PMID: 30318341]
[108]
Chen, M.X.; Wang, S.Y.; Kuo, C.H.; Tsai, I.L. Metabolome analysis for investigating host-gut microbiota interactions. J. Formos. Med. Assoc., 2018, S0929, 30619.
[PMID: 30269936]
[109]
Tay, J.; Thompson, C.H.; Luscombe-Marsh, N.D.; Wycherley, T.P.; Noakes, M.; Buckley, J.D.; Wittert, G.A.; Yancy, W.S., Jr; Brinkworth, G.D. Effects of an energy-restricted low-carbohydrate, high unsaturated fat/low saturated fat diet versus a high-carbohydrate, low-fat diet in type 2 diabetes: A 2-year randomized clinical trial. Diabetes Obes. Metab., 2018, 20(4), 858-871.
[http://dx.doi.org/10.1111/dom.13164] [PMID: 29178536]
[110]
Lean, M.E.; Leslie, W.S.; Barnes, A.C.; Brosnahan, N.; Thom, G.; McCombie, L.; Peters, C.; Zhyzhneuskaya, S.; Al-Mrabeh, A.; Hollingsworth, K.G.; Rodrigues, A.M.; Rehackova, L.; Adamson, A.J.; Sniehotta, F.F.; Mathers, J.C.; Ross, H.M.; McIlvenna, Y.; Stefanetti, R.; Trenell, M.; Welsh, P.; Kean, S.; Ford, I.; McConnachie, A.; Sattar, N.; Taylor, R. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 2018, 391(10120), 541-551.
[http://dx.doi.org/10.1016/S0140-6736(17)33102-1] [PMID: 29221645]
[111]
De Lorenzo, A.; Maiolo, C.; Mohamed, E.I.; Andreoli, A.; Petrone-De Luca, P.; Rossi, P. Body composition analysis and changes in airways function in obese adults after hypocaloric diet. Chest, 2001, 119(5), 1409-1415.
[http://dx.doi.org/10.1378/chest.119.5.1409] [PMID: 11348946]
[112]
Dulloo, A.G.; Miles-Chan, J.L.; Schutz, Y. Collateral fattening in body composition autoregulation: its determinants and significance for obesity predisposition. Eur. J. Clin. Nutr., 2018, 72(5), 657-664.
[http://dx.doi.org/10.1038/s41430-018-0138-6] [PMID: 29559726]
[113]
Colica, C.; Merra, G.; Gasbarrini, A.; De Lorenzo, A.; Cioccoloni, G.; Gualtieri, P.; Perrone, M.A.; Bernardini, S.; Bernardo, V.; Di Renzo, L.; Marchetti, M. Efficacy and safety of very-low-calorie ketogenic diet: a double blind randomized crossover study. Eur. Rev. Med. Pharmacol. Sci., 2017, 21(9), 2274-2289.
[PMID: 28537652]
[114]
Merra, G.; Gratteri, S.; De Lorenzo, A.; Barrucco, S.; Perrone, M.A.; Avolio, E.; Bernardini, S.; Marchetti, M.; Di Renzo, L. Effects of very-low-calorie diet on body composition, metabolic state, and genes expression: a randomized double-blind placebo-controlled trial. Eur. Rev. Med. Pharmacol. Sci., 2017, 21(2), 329-345.
[PMID: 28165552]
[115]
Merra, G.; Miranda, R.; Barrucco, S.; Gualtieri, P.; Mazza, M.; Moriconi, E.; Marchetti, M.; Chang, T.F.; De Lorenzo, A.; Di Renzo, L. Very-low-calorie ketogenic diet with aminoacid supplement versus very low restricted-calorie diet for preserving muscle mass during weight loss: a pilot double-blind study. Eur. Rev. Med. Pharmacol. Sci., 2016, 20(12), 2613-2621.
[PMID: 27383313]
[116]
De Lorenzo, A.; Bernardini, S.; Gualtieri, P.; Cabibbo, A.; Perrone, M.A.; Giambini, I.; Di Renzo, L. Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk. Acta Diabetol., 2017, 54(2), 141-149.
[http://dx.doi.org/10.1007/s00592-016-0917-2] [PMID: 27709360]
[117]
Di Renzo, L.; Colica, C.; Carraro, A.; Cenci Goga, B.; Marsella, L.T.; Botta, R.; Colombo, M.L.; Gratteri, S.; Chang, T.F.; Droli, M.; Sarlo, F.; De Lorenzo, A. Food safety and nutritional quality for the prevention of non communicable diseases: the Nutrient, hazard Analysis and Critical Control Point process (NACCP). J. Transl. Med., 2015, 13, 128.
[http://dx.doi.org/10.1186/s12967-015-0484-2] [PMID: 25899825]
[118]
Hood, L. Systems biology and p4 medicine: past, present, and future. Rambam Maimonides Med. J., 2013, 4(2), e0012
[http://dx.doi.org/10.5041/RMMJ.10112] [PMID: 23908862]


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VOLUME: 27
ISSUE: 2
Year: 2020
Published on: 18 February, 2020
Page: [216 - 229]
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DOI: 10.2174/0929867326666190326113607
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