Oxidative stress is implicated in the etiology of many ethanol-induced pathologies.
Oxidative stress has been shown to contribute to the development of endothelial dysfunction and
cardiovascular disease, such as hypertension. This review details mechanisms of vascular function,
the role of oxidative stress in vascular biology and how ethanol consumption may alter endothelial
and smooth muscle cell function as well as microvascular function. Also reviewed are data from
human investigations that have examined the association between alcohol consumption and changes
in blood pressure and increased risk for hypertension.
Keywords: Alcohol, oxidative stress, vasculature, ethanol-induced pathologies, hypertension, microvascular function.
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