Multi-component Preparation of Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines Using Solvent-free and HSBM Techniques

Author(s): Seyyed Jalal Roudbaraki, Morteza Ziyaadini, Majid Ghashang*.

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 7 , 2020

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Abstract:

Simple and clean access to pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidine derivatives using solvent- free and HSBM techniques through the multi-component reaction of 3-methyl-1-phenyl-1Hpyrazol- 5-amine, 1-aryl-2-thiocyanatoethan-1-one and aromatic aldehydes are reported. Using 2-hydroxyethan-1-aminium acetate as an ionic liquid, the product in high yields is obtained.

Keywords: Pyrazolo[3, 4-d]thiazolo[3, 2-a]pyrimidine, Thiazolo[3, 2-a]pyrimidine, HSBM technique, 2-hydroxyethan-1- aminium acetate, Ionic liquid, multi-component reaction.

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Article Details

VOLUME: 17
ISSUE: 7
Year: 2020
Page: [512 - 516]
Pages: 5
DOI: 10.2174/1570178616666190319155522
Price: $65

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