Premature ovarian failure (POF) is characterized by amenorrhea, hypergonadotropism and
hypoestrogenism before the age of 40, which affects 1% of women in the general population. POF is
complex and heterogeneous due to its pathogenetic mechanisms. It is one of the significant causes of
female infertility. Although many treatments are available for POF, these therapies are less efficient and
trigger many side effects. Therefore, to find effective therapeutics for POF is urgently required. Due to
stem cells having self-renewal and regeneration potential, they may be effective for the treatment of ovarian
failure and consequently infertility. Recent studies have found that stem cells therapy may be able to
restore the ovarian structure and function in animal models of POF and provide an effective treatment
method. The present review summarizes the biological roles and the possible signaling mechanisms of the
different stem cells in POF ovary. Further study on the precise mechanisms of stem cells on POF may
provide novel insights into the female reproduction, which not only enhances the understanding of the
physiological roles but also supports effective therapy for recovering ovarian functions against infertility.
Keywords: Premature ovarian failure, stem cells, ovary, gonadotropin, amenorrhea, hypergonadotropism, hypoestrogenism.
Akyash F, Aflatoonian A, Rezazadeh Valojerdi M, Sadeghian Nodoushan F, Aflatoonian R, Aflatoonian B. In Vitro Isolation, Culture and Identification of Human Endometrial Mesenchymal Stem/Stromal Cells (EnMSCs). Cell J 2015; 17(Suppl. 1): 21-2.
Akyash F, Sadeghian-Nodoushan F, Aflatoonian B. Isolation, Culture and Characterization of Human Endometrial Mesenchymal Stem/Stromal Cells (EnMSCs): A Mini Review. Austin J In Vitro Fertili 2016; 3(1): 1025.
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