Objective: Current treatment options for Allergic Rhinitis (AR) may have their own limitations
and side effects. This study aimed to investigate the effects of Ma-al-Shaeer (MS), a novel natural
formulation based on Hordeum vulgare, in the treatment of AR compared with Fexofenadine (FX).
Methods: A total of 77 patients with AR were divided into two groups: MS group (n=38) and FX
group (n=39). The first group received 15 g of dried MS powder, and the second group received 60 mg
of FX twice daily for 14 days. At baseline (week zero) and after the 14-day treatment period (week
two), both groups were evaluated for sneezing, rhinorrhea, nasal congestion, nasal itching, post nasal
drip, eye, throat, or ear symptoms, headache, cough, mental function, quality of life scores, blood
eosinophil count and total IgE levels. Rhinitis control assessment tests were conducted at week zero
and again at one week after cessation of treatment (week three) in both groups.
Results: All symptoms of AR except cough were significantly reduced in both groups; for nasal congestion,
post nasal drip, and headache, the MS treatment was found to be superior. Rhinitis control was
significantly increased after treatment in both groups (p value < 0.001). Both drugs significantly reduced
total IgE levels. There was no significant change in eosinophil count in either group.
Conclusion: MS formulation based on H. vulgare may be an effective treatment for AR. Further studies
are needed to confirm the effect of MS as an alternative treatment in AR.