Crosstalk between the CX3CL1/CX3CR1 Axis and Inflammatory Signaling Pathways in Tissue Injury

Author(s): Quan Zhuang, Jiarui Ou, Sheng Zhang, Yingzi Ming*

Journal Name: Current Protein & Peptide Science

Volume 20 , Issue 8 , 2019

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Graphical Abstract:


During inflammation, chemokines play a central role by mediating the activation of inflammatory cascade responses in tissue injury. Among more than 200 chemokines, CX3CL1 is a special chemotactic factor existing in both membrane-bound and soluble forms. Its only receptor, CX3CR1, is a member of the G protein-coupled receptor superfamily. The CX3CL1/CX3CR1 axis can affect many inflammatory processes by communicating with different inflammatory signaling pathways, such as JAK-STAT, Toll-like receptor, MAPK, AKT, NF-κB, Wnt/β-catenin, as well as others. These inflammatory networks are involved in much pathology. Determining the crosstalk between the CX3CL1/CX3CR1 axis and these inflammatory signaling pathways could contribute to solving problems in tissue injury, and the CX3CL1/CX3CR1 axis may be a better therapeutic target than inflammatory signaling pathways for preventing tissue injury due to the complexity of inflammatory signaling networks.

Keywords: CX3CL1, CX3CR1, inflammatory signaling pathway, tissue injury, chemokines, pathology.

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Article Details

Year: 2019
Published on: 07 July, 2019
Page: [844 - 854]
Pages: 11
DOI: 10.2174/1389203720666190305165722
Price: $65

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