Serum Thiol-Disulphide Levels in Epileptic Pediatric Patients

Author(s): Halit Halil*, Nilden Tuygun, Erhan Aksoy, Ozcan Erel, Can Demir Karacan

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 22 , Issue 1 , 2019

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Background: Epilepsy is a serious clinical condition characterized by recurrent seizures. Oxidative stress plays an important role in the etio-pathogenesis of epilepsy. Measurements of serum thiol and disulfide levels were used to evaluate the antioxidant status of the body.

Objective: The aim of this study was to determine serum levels of thiol and disulfide in epileptic pediatric patients.

Methods: Ninety patients, 54 epilepsy and 36 controls were included in the study. Serum levels of native thiol total thiol and disulfide were measured and disulfide/native, disulfide / total thiol and native thiol/ total thiol ratios were calculated. Hence, the ratios of disulfide/ native thiol, disulfide / total thiol and native thiol/ total thiol were calculated.

Results: Serum levels of native thiol, total thiol and disulfide were significantly lower in the epilepsy group than the control group. The ratio of disulfide/native thiol and disulfide / total thiol were significantly higher in the study group than the control group. As well as, the native thiol / total thiol ratio was lower in the epilepsy group than the control group. Native thiol, total thiol and disulfide were significantly lower in the epilepsy group who were taking anti-epileptic drugs than those who were not taking anti-epileptic drugs.

Conclusion: We demonstrated a meaningful relationship between oxidative stress markers and epilepsy in pediatric patients.

Keywords: Biomarkers, disulfide, epilepsy, pediatrics, thiol, oxidative stress.

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Article Details

Year: 2019
Published on: 03 May, 2019
Page: [65 - 68]
Pages: 4
DOI: 10.2174/1386207322666190305135043
Price: $65

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