Title:Serum Thiol-Disulphide Levels in Epileptic Pediatric Patients
VOLUME: 22 ISSUE: 1
Author(s):Halit Halil*, Nilden Tuygun, Erhan Aksoy, Ozcan Erel and Can Demir Karacan
Affiliation:Division of Pediatric Emergency, University of Health Sciences, Dr. Sami Ulus Maternity and Children's Research and Training Hospital, Ankara, Division of Pediatric Emergency, University of Health Sciences, Dr. Sami Ulus Maternity and Children's Research and Training Hospital, Ankara, Department of Pediatric Neurology, Yildirim Beyazit University, Ankara, Department of Biochemistry, Yildirim Beyazit University, Ankara, Division of Pediatric Emergency, University of Health Sciences, Dr. Sami Ulus Maternity and Children's Research and Training Hospital, Ankara
Keywords:Biomarkers, disulfide, epilepsy, pediatrics, thiol, oxidative stress.
Abstract:
Background: Epilepsy is a serious clinical condition characterized by recurrent seizures.
Oxidative stress plays an important role in the etio-pathogenesis of epilepsy. Measurements of
serum thiol and disulfide levels were used to evaluate the antioxidant status of the body.
Objective: The aim of this study was to determine serum levels of thiol and disulfide in epileptic
pediatric patients.
Methods: Ninety patients, 54 epilepsy and 36 controls were included in the study. Serum levels of
native thiol total thiol and disulfide were measured and disulfide/native, disulfide / total thiol and
native thiol/ total thiol ratios were calculated. Hence, the ratios of disulfide/ native thiol, disulfide /
total thiol and native thiol/ total thiol were calculated.
Results: Serum levels of native thiol, total thiol and disulfide were significantly lower in the
epilepsy group than the control group. The ratio of disulfide/native thiol and disulfide / total thiol
were significantly higher in the study group than the control group. As well as, the native thiol /
total thiol ratio was lower in the epilepsy group than the control group. Native thiol, total thiol and
disulfide were significantly lower in the epilepsy group who were taking anti-epileptic drugs than
those who were not taking anti-epileptic drugs.
Conclusion: We demonstrated a meaningful relationship between oxidative stress markers and
epilepsy in pediatric patients.
