Background: In this review, protein-protein interactions (PPIs) were defined, and their behaviors
in normal in disease conditions are discussed. Their status at nuclear, molecular and cellular
level was underscored, as for their interference in many diseases. Finally, the use of protein nanoscale
structures as possible carriers for drugs targeting PPIs was highlighted.
Objective: The objective of this review is to suggest a novel approach for targeting PPIs. By using protein
nanospheres and nanocapsules, a promising field of study can be emerged.
Methods: To solidify this argument, PPIs and their biological significance was discussed, same as their
role in hormone signaling.
Results: We shed the light on the drugs that targets PPI and we suggested the use of nanovectors to encapsulate
these drugs to possibly achieve better results.
Conclusion: Protein based nanoparticles, due to their advantages, can be suitable carriers for drugs targeting
PPIs. This can open a new opportunity in the emerging field of multifunctional therapeutics.