Atherosclerosis and Nanomedicine Potential: Current Advances and Future Opportunities

Author(s): Fan Jiang, Yunqi Zhu, Changyang Gong*, Xin Wei*

Journal Name: Current Medicinal Chemistry

Volume 27 , Issue 21 , 2020

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Abstract:

Atherosclerosis is the leading inducement of cardiovascular diseases, which ranks the first cause of global deaths. It is an arterial disease associated with dyslipidemia and changes in the composition of the vascular wall. Besides invasive surgical strategy, the current conservative clinical treatment for atherosclerosis falls into two categories, lipid regulating-based therapy and antiinflammatory therapy. However, the existing strategies based on conventional drug delivery systems have shown limited efficacy against disease development and plenty of side effects. Nanomedicine has great potential in the development of targeted therapy, controlled drug delivery and release, the design of novel specific drugs and diagnostic modalities, and biocompatible scaffolds with multifunctional characteristics, which has led to an evolution in the diagnosis and treatment of atherosclerosis. This paper will focus on the latest nanomedicine strategies for atherosclerosis diagnosis and treatment as well as discussing the potential therapeutic targets during atherosclerosis progress, which could form the basis of development of novel nanoplatform against atherosclerosis.

Keywords: Atherosclerosis, cardiovascular diseases, nanomedicine, drug delivery system, diagnosis, treatment, theranostics, scaffolds.

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