K2CO3 Promoted Cascade Reaction for the Preparation of 1H-Imidazol-4- yl-1-amine Derivatives

Author(s): Wei Xu, Hao Yao, Xing Zhang, Changjiang Peng, Ling Li, Yuanyuan Zhang, Shan Qian, Lingling Yang*, Zhouyu Wang*

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 2 , 2020

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Abstract:

A K2CO3 promoted efficient one pot two-step method for the preparation of 1H-imidazol-4- yl-1-amine derivatives has been developed. A series of second amines with an imidazole group were obtained with 56%-91% yields by the K2CO3 promoted amination of acetates and nitrogen deprotection of the imidazole process.

Keywords: One pot, second amine, imidazole, nucleophilic displacement, K2CO3, amination.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2020
Page: [127 - 132]
Pages: 6
DOI: 10.2174/1570178616666190226144620
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