Background: Increased parathyroid hormone (PTH) level is associated with coronary artery
disease, hypertension and left ventricular hypertrophy which are all predisposing factors for the
ischemic cerebrovascular event (ICVE). Carotid intima-media thickness (CIMT) and aortic distensibility
are the two early, subclinical predictors of atherosclerosis. The relation of PTH with CIMT and
aortic distensibility in patients with ICVE has not been previously studied.
Objective: Our aim was to study the relationship of PTH levels with aortic distensibility and CIMT in
patients with ICVE.
Methods: Sixty-four ICVE patients and 50 control group were enrolled in the study. PTH levels, aortic
distensibility and CIMT were measured in all individuals.
Results: PTH levels were significantly higher in ICVE patients than in the controls (60.1±21.6 vs.
52.3±6.2 pg/ml) (p=0. 008). PTH levels were found to be inversely correlated with aortic distensibility
(r= -0. 420, p=0.001) and positively correlated with CIMT (r:0, 285, p=0,002).
Conclusion: The present study shows that PTH levels are increased in patients with acute ischemic
cerebrovascular event compared to the control group. It also demonstrates that PTH levels are inversely
related to aortic distensibility of ascending aorta and positively associated with CIMT.