Polycyclic Aromatic Hydrocarbons in Foods: A Critical Review

Author(s): Samuel A.O. Adeyeye*

Journal Name: Current Nutrition & Food Science

Volume 16 , Issue 6 , 2020

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Abstract:

Objective: Polycyclic aromatic hydrocarbons (PAHs) are well researched chemicals in foods that have been found to exhibit mutagenic and carcinogenic potentials. This study examined available literature on polycyclic aromatic hydrocarbons in foods, sources, effects and remediation.

Method: Available literature on polycyclic aromatic hydrocarbons in foods, sources, effects and remediation was critically reviewed.

Results: The review showed that carcinogenicity of PAHs varies from the potent to moderately carcinogenic PAHs which include 3-methylcholanthrene, Benzo[a]pyrene, dibenz[a,h]anthracene, 5-methylchrysene, and dibenz[a,j]anthracene, whereas benzo[e]pyrene, dibenz[a,c]anthracene, chrysene, benzo[c]phenanthrene and fluoranthene are relatively weak or inactive carcinogens. Cooking processes have been found to be a major source of PAHs in foods. Although, PAHs can also be formed during curing and processing of raw food prior to cooking, several researchers in recent years have shown that the major dietary sources of PAHs are fish and meat especially where there is high consumption of meat cooked over an open flame. Several procedures and methods have been developed recently to assess and detect PAHs in foods and more recently, bio-monitoring procedures have also been developed to assess human exposure to PAHs. Numerous organizations such as the United States Environmental Protection Agency (U.S. EPA), the International Agency for Research on Cancer (IACR), the Scientific Committee on Food (SCF), the Joint FAO/WHO Expert Committee on Food Additives (JECFA), the International Programme on Chemical Safety (IPCS), and the European Food Safety Authority (EFSA) have been involved in evaluating the occurrence and toxicity of PAHs.

Conclusion: Conclusively, taking into consideration the sources of PAHs generation, adequate process and quality control of the processed foods could be a veritable mean to reduce PAHs ingestion in foods.

Keywords: Carcinogenic, detection, foods, health, PAHs, cooking process.

[1]
Mastral AM, Callén M. A review on polycyclic aromatic hydrocarbon (PAH) emissions from energy generation. Environ Sci Technol 2000; 34: 3051-7.
[http://dx.doi.org/10.1021/es001028d]
[2]
Harvey RG. Polycyclic aromatic hydrocarbons. New York: Wiley-VCH 1997.
[3]
Howsam M, Jones K. Sources of PAHs in the Environment. In: Neilson AH, Ed. PAHs and Related Compounds. Berlin, Heidelberg: Springer 1998; pp. 137-74.
[http://dx.doi.org/10.1007/978-3-540-49697-7_4]
[4]
Adeyeye SAO, Oyewole OB, Obadina AO, Omemu AM, Oyedele HA. Quality characteristics and chemical safety of fried and smoked West Africa Ilisha (Ilisha africana) from Ibadan, Oyo State, Nigeria. Nutr Food Sci 2016; 46(2): 246-58.
[http://dx.doi.org/10.1108/NFS-10-2015-0119]
[5]
Adeyeye SAO, Oyewole OB, Obadina O, et al. Effect of smoking methods on microbial safety, polycyclic aromatic hydrocarbon, and heavy metal concentrations of traditional smoked fish from Lagos State, Nigeria. J Culin Sci Technol 2016; 14(2): 91-106.
[http://dx.doi.org/10.1080/15428052.2015.1080644]
[6]
Mottier P, Parisod V, Turesky RJ. Quantitative determination of polycyclic aromatic hydrocarbons in barbecued meat sausages by gas chromatography coupled to mass spectrometry. J Agric Food Chem 2000; 48(4): 1160-6.
[http://dx.doi.org/10.1021/jf991205y] [PMID: 10775366]
[7]
Tamakawa K. Polycyclic aromatic hydrocarbons in foods.In: Nollet LML, Toldrá F, Eds. Handbook of food analysis. New York: Marcel Dekker Inc. 2004; pp. 1449-83.
[8]
Moffat CF, Whittle KJ. Polycyclic aromatic hydrocarbons, petroleum and other hydrocarbon contaminants.Moffat C, Whittle KJ,Eds. Environmental contaminants of food. Sheffield: SheffieldAcademic Press 1999; pp. 364-429.
[9]
Moret S, Conte LS. Polycyclic aromatic hydrocarbons in edible fats and oils: occurrence and analytical methods. J Chromatogr A 2000; 882(1-2): 245-53.
[http://dx.doi.org/10.1016/S0021-9673(00)00079-0] [PMID: 10895949]
[10]
Moreda W, Pérez-Camino MC, Cert A. Gas and liquid chromatography of hydrocarbons in edible vegetable oils. J Chromatogr A 2001; 936(1-2): 159-71.
[http://dx.doi.org/10.1016/S0021-9673(01)01222-5] [PMID: 11760997]
[11]
Ravindra K, Sokhi R, Van Grieken R. Atmospheric polycyclic aromatic hydrocarbons: Source attribution, emission factors and regulation. Atmos Environ 2000; 42(13): 2895-921.
[http://dx.doi.org/10.1016/j.atmosenv.2007.12.010]
[12]
Ramesh A, Archibong A, Hood DB, Guo Z, Loganathan BG. Global environmental distribution and human health effects of polycyclic aromatic hydrocarbons Global Contamination Trends of Persistent Organic Chemicals. Boca Raton, FL: CRC Press 2011; pp. 97-126.
[http://dx.doi.org/10.1201/b11098-7]
[13]
Choi H, Harrison R, Komulainen H, Delgado SJ. Polycyclic aromatic hydrocarbons WHO Guidelines for Indoor Air Quality: Selected Pollutants. Geneva: World Health Organization 2010.
[14]
Phillips DH. Polycyclic aromatic hydrocarbons in the diet. Mutat Res 1999; 443(1-2): 139-47.
[http://dx.doi.org/10.1016/S1383-5742(99)00016-2] [PMID: 10415437]
[15]
Zelinkova Z, Wenzl T. The occurrence of 16 EPA PAHs in food - A review. Polycycl Aromat Compd 2015; 35(2-4): 248-84.
[http://dx.doi.org/10.1080/10406638.2014.918550] [PMID: 26681897]
[16]
Cooke MISOPAH. Polynuclear Aromatic Hydrocarbons: Physical and Biological Chemistry presented at the Sixth International Symposium (on Polynu-clear Aromatic Hydrocarbons), Oct 27-29,1981, Battelle Co-lumbus Laboratories, (Columbus, Ohio: Battelle Press, 1982).
[17]
Edwards NT. Polycyclic aromatic hydrocarbons (PAH’s) in the terrestrial environment - A review. J Environ Qual 1983; 12: 427-41.
[http://dx.doi.org/10.2134/jeq1983.00472425001200040001x]
[18]
Nielsen T, Jørgensen HE, Larsen JC, Poulsen M. City air pollution of polycyclic aromatic hydrocarbons and other mutagens: occurrence, sources and health effects. Sci Total Environ 1996; 189-190: 41-9.
[http://dx.doi.org/10.1016/0048-9697(96)05189-3] [PMID: 8865676]
[19]
Afolabi OA, Adesulu EA, Oke OL. Polynuclear aromatic hydrocarbons in some Nigerian preserved freshwater fish species. J Agric Food Chem 1983; 31(5): 1083-90.
[http://dx.doi.org/10.1021/jf00119a040] [PMID: 6685147]
[20]
Fretheim K. Polycyclic aromatic hydrocarbons in grilled meat products—A review. Food Chem 1983; 10: 129-39.
[http://dx.doi.org/10.1016/0308-8146(83)90029-8]
[21]
Martena MJ, Grutters MMP, De Groot HN, Konings EJM, Rietjens IM. Monitoring of polycyclic aromatic hydrocarbons (PAH) in food supplements containing botanicals and other ingredients on the Dutch market. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2011; 28(7): 925-42.
[http://dx.doi.org/10.1080/19440049.2011.569573] [PMID: 21574084]
[22]
Davídek J. Natural toxic compounds of foods formation and change during processing and storage. Boca Raton, FL: CRC Press Inc. 1995.
[23]
Adeyeye SAO, Oyewole OB, Obadina O, Omemu AM, Omoniyi SA. Quality attributes, polycyclic aromatic hydrocarbon, and heavy metal profile of traditional drum-smoked Guinean barracuda fish from Lagos State, Nigeria. J Aquat Food Prod Technol 2017; 26(3): 296-307.
[http://dx.doi.org/10.1080/10498850.2016.1155191]
[24]
Simko P. Determination of polycyclic aromatic hydrocarbons in smoked meat products and smoke flavouring food additives. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 770(1-2): 3-18.
[http://dx.doi.org/10.1016/S0378-4347(01)00438-8] [PMID: 12013240]
[25]
Houessou JK, Maloug S, Leveque A-S, Delteil C, Heyd B, Camel V. Effect of roasting conditions on the polycyclic aromatic hydrocarbon content in ground Arabica coffee and coffee brew. J Agric Food Chem 2007; 55(23): 9719-26.
[http://dx.doi.org/10.1021/jf071745s] [PMID: 17941690]
[26]
Pincemaille J, Schummer C, Heinen E, Moris G. Determination of polycyclic aromatic hydrocarbons in smoked and non-smoked black teas and tea infusions. Food Chem 2014; 145: 807-13.
[http://dx.doi.org/10.1016/j.foodchem.2013.08.121] [PMID: 24128549]
[27]
Scientific Committee on Food (SCF) Opinion of the Scientific Committee on Food on the Risks to Human Health of Polycyclic Aromatic Hydrocarbons in Food. 2002.
[28]
Resolução RDC n281 de 06 de outubro de Diário Ofi-cial da União 2003.
[29]
Portaria MS n518 de 25 de março de Diário Oficial da União 2004.
[30]
Resolução RDC n2 de 15 de janeiro de Diário Oficial da União 2007.
[31]
Borokovcova I, Dofkova M, Rehurkova I, Ruprich J. Polycyclic aromatic hydrocarbons in the Czech foods stuffs in the year 2004. Chem Listy 2005; 99: 268-70.
[32]
Ciecierska M, Obiedziński MW. Polycyclic aromatic hydrocarbons in the bakery chain. Food Chem 2013; 141(1): 1-9.
[http://dx.doi.org/10.1016/j.foodchem.2013.03.006] [PMID: 23768318]
[33]
Rey-Salgueiro L, Garcia-Falcón MS, Soto-Gonzalez B, Simal-Gándara J. Occurrence of polycyclic aromatic hydrocarbons and their hy-droxylated metabolites in infant foods. Food Chem 2009; 115: 814-9.
[http://dx.doi.org/10.1016/j.foodchem.2008.12.095]
[34]
WHO. Polycyclic Aromatic Hydrocarbons WHO Food Addi-tives Series 55: Safety evaluation of certain contaminants in food 2006; 563-743.
[35]
Association of Official Analytical Chemists. AOAC Official Method of Analysis 1975. 385-8
[36]
ISO/IEC 17025 General Requirements for the Competence of Testing and Calibration Laboratories 1975.
[37]
International Standardization Organization (ISO) ISO. 2009; 22959.
[38]
International Standardization Organization (ISO) ISO. 2007; 15302.
[39]
International Standardization Organization (ISO) PD ISO/TR 24054
[40]
Plaza-Bolaños P, Frenich AG, Vidal JL. Polycyclic aromatic hydrocarbons in food and beverages. Analytical methods and trends. J Chromatogr A 2010; 1217(41): 6303-26.
[http://dx.doi.org/10.1016/j.chroma.2010.07.079] [PMID: 20828703]
[41]
Wise SA, Hilpert LR, Byrd GD, May WE. Comparison of liquid chromatography with fluorescence detection and gas chromatography/mass spectrometry for the determination of polycyclic aromatic hydrocarbons in environmental samples. Polycycl Aromat Compd 1990; 1: 81-98.
[http://dx.doi.org/10.1080/10406639008034751]
[42]
Cai S-S, Stevens J, Syage JA. Ultra high performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry for high-sensitivity analysis of US Environmental Protection Agency sixteen priority pollutant polynuclear aromatic hydrocarbons in oysters. J Chromatogr A 2012; 1227: 138-44.
[http://dx.doi.org/10.1016/j.chroma.2011.12.111] [PMID: 22265780]
[43]
Cai S-S, Syage JA, Hanold KA, Balogh MP. Ultra performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry for high-sensitivity and high-throughput analysis of U.S. Environmental Protection Agency 16 priority pollutants polynuclear aromatic hydrocarbons. Anal Chem 2009; 81(6): 2123-8.
[http://dx.doi.org/10.1021/ac802275e] [PMID: 19227980]
[44]
Short LC, Cai S-S, Syage JA. APPI-MS: effects of mobile phases and VUV lamps on the detection of PAH compounds. J Am Soc Mass Spectrom 2007; 18(4): 589-99.
[http://dx.doi.org/10.1016/j.jasms.2006.11.004] [PMID: 17188507]
[45]
Schiewek R, Schellenträger M, Mönnikes R, et al. Ultrasensitive determination of polycyclic aromatic compounds with atmospheric-pressure laser ionization as an interface for GC/MS. Anal Chem 2007; 79(11): 4135-40.
[http://dx.doi.org/10.1021/ac0700631] [PMID: 17472342]
[46]
Scientific Opinion of the Panel on Contaminants in the Food Chain on a request from the European Commission on Polycyclic Aromatic Hydrocarbons in Food. EFSA J 2008; 724: 1-114.
[47]
Adeyeye SAO. Heterocyclic amines and polycyclic aromatic hydrocarbons in cooked meat products: a reviewPolycycl Aromat Comp 2018; Available from: https://www.tandfonline.com/doi/ full/10.1080/10406638.2018.1559208
[http://dx.doi.org/10.1080/10406638.2018.1559208]
[48]
Codex Alimentarius International Food StandardsCode of Practice for the Reduction of Contamination of Food with Polycyclic Aromatic Hydrocarbons (PAH) from Smoking and Direct Drying Processes Codex Alimentarius, CAC/RCP 68-2009 2009.
[49]
European Union Commission Recommendation of February 4, on the Further Investigation into the Levels of Polycyclic Aromatic Hydrocarbons in Certain Foods (2005/108/EC) Of-ficial Journal of European Union L34/43 2005.
[50]
European Union Commission Regulation (EU) No 836/2011 Official Journal of European Union L215/9 836/201 2011.
[51]
Bugang W, Woolsey MU. Service. (Beijing: USDA Foreign Agricultural Service. National Food Safety Standard-Maximum Levels of Contami-nants in Food 2010.
[52]
Perera F, Tang D, Whyatt R, Lederman SA, Jedrychowski W. DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center Area, Poland, and China. Cancer Epidemiol Biomarkers Prev 2005; 14(3): 709-14.
[http://dx.doi.org/10.1158/1055-9965.EPI-04-0457] [PMID: 15767354]


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Article Details

VOLUME: 16
ISSUE: 6
Year: 2020
Published on: 15 July, 2020
Page: [866 - 873]
Pages: 8
DOI: 10.2174/1573401315666190215112216
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