Synthesis, Conformational Analysis and Crystal Structure of New Thioxo, Oxo, Seleno Diastereomeric Cyclophosphamides Containing 1,3,2-dioxaphosphorinane

Author(s): Dorra Kanzari-Mnallah, Med L. Efrit, Jiří Pavlíček, Frédéric Vellieux, Habib Boughzala, Azaiez B. Akacha*

Journal Name: Current Organic Chemistry

Volume 23 , Issue 2 , 2019


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Abstract:

Thioxo, Oxo and Seleno diastereomeric cyclophosphamides containing 1,3,2- dioxaphosphorinane are prepared by a one-step chemical reaction. Their structural determination is carried out by means of Nuclear Magnetic Resonance NMR (31P, 1 H, 13C) and High-Resolution Mass Spectroscopy (HRMS). The conformational study of diastereomeric products is described. Density Functional Theory (DFT) calculations allowed the identification of preferred conformations. Experimental and calculated 31P, 13C, 1H NMR chemical shifts are compared. The molecular structure of the 2-Benzylamino-5-methyl-5- propyl-2-oxo-1,3,2-dioxaphosphorinane (3d) has been determined by means of crystal Xray diffraction methods.

Keywords: Cyclophosphamide, diastereomeric 1, 3, 2-dioxaphosphorinane, NMR (31P, 1 H, 13C) analysis, DFT calculation, GIAO method, X-ray structure.

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Article Details

VOLUME: 23
ISSUE: 2
Year: 2019
Published on: 22 April, 2019
Page: [205 - 213]
Pages: 9
DOI: 10.2174/1385272823666190213142748
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