Synthesis and Molecular Docking of New Thiophene Derivatives as Lactate Dehydrogenase-A Inhibitors

Author(s): Abd El-Galil E. Amr*, Mohamed F. El-Shehry, Alhussein A. Ibrahim, Hanaa M. Hosni, Mohamed A. Al-Omar, Hazem A. Ghabbour

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 19 , Issue 10 , 2019

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Graphical Abstract:


Background & Objective: A series of novel derivatives possessing the thiophene moiety were synthesized using ethyl 5'-amino-2,3'-bithiophene-4'-carboxylate as the starting material.

Methods: The new synthesized derivatives were screened as lactate dehydrogenase (LDH) inhibitors. LDH plays an important role in glucose metabolism in cancer cells and can affect tumor genesis and metastasis.

Results: 3-Substituted p-tolylthieno[2,3-d]pyrimidin-4(3H)-ones 4 were the most potent inhibitors in this study compared to Galloflavin reference drug.

Conclusion: Molecular docking studies on the Human Lactate Dehydrogenase active site were carried out on the synthesized compounds and the MolDock scores ranged between -127 to -171.

Keywords: Thiophene derivatives, thieno[2, 3-d]pyrimidin-4(3H)-ones, molecular modeling, lactate dehydrogenase inhibitors, anticancer drug target, tumor genesis.

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Article Details

Year: 2019
Published on: 28 May, 2019
Page: [833 - 841]
Pages: 9
DOI: 10.2174/1389557519666190212165302
Price: $65

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