Objective: In this study, it was aimed to prepare an electrochemical sensor capable of assigning
Norepinephrine in the presence of an interference such as ascorbic acid.
Methods: A sensitive modified sensor was prepared by electrodeposition of p-aminobenzenesulfonic
acid (p-ABSA) to the glassy carbon electrode by cyclic voltammetry. The electrooxidation of Norepinephrine
was accomplished by cyclic and differential pulse voltammetry.
Results: The current values were enhanced and the peak potentials of Norepinephrine and ascorbic acid
were separated at the sensor compared to the bare electrode. There was linearity between the oxidation
current and concentration of Norepinephrine ranging from 0.5 to 99.8 μM in phosphate buffer solution
at pH 7.0. The limit of detection was 10.0 nM and the sensitivity was 0.455 μA/μM.
Conclusion: The determination of Norepinephrine was successfully performed in real samples such as
blood serum and urine at the poly (p-ABSA) sensor. To the best of our knowledge, this is the first study
to detect Norepinephrine in the presence of ascorbic acid at poly (p-ABSA) modified sensor in the literature.