Background: Due to emerging resistances against antibiotics there is a strong need to
find novel antibacterial agents with a novel structure to prevent early resistance developments.
Objective: Bisindole compounds with antibacterial activities which formally result from the reaction
of an aldehyde with indole motivated to investigate the reaction of a dialdehyde and indole to
give novel structures with potential antibacterial activities.
Methods: Compounds were yielded by chemical synthesis and purified using column chromatography.
The antibacterial activity was determined as minimal inhibitory growth activity in cultures
of Gram-positive strains of Staphylococcus aureus and Enterococcus species.
Results: Cyclohepta[2,3-b]indoles have been yielded in a one-step reaction procedure with indole
substitutions at the cycloheptane central core matching a solution for achieving fused novel cycloalkane
indoles with functionalized residues of promising biological activity. So far fused cycloalkane
indoles have not been available in a one-step procedure and moreover, core functionalizations
have been additional challenges. Various indole substitutions have been done to provide a
first set of compounds.
Conclusion: Substituent-dependent effects have been suggested to influence the antibacterial activity
and first compounds were identified with specific Staphylococcus activities and Enterococcus
species effects towards Enterococcus faecalis as critical pathogens in the hospital with upcoming
resistances against standard antibiotics.