Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains

Author(s): Andreas Hilgeroth*, Kaveh Yasrebi, Sibel Suzen, Tobias Hertlein, Knut Ohlsen, Michael Lalk

Journal Name: Medicinal Chemistry

Volume 15 , Issue 8 , 2019

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Graphical Abstract:


Background: Due to emerging resistances against antibiotics there is a strong need to find novel antibacterial agents with a novel structure to prevent early resistance developments.

Objective: Bisindole compounds with antibacterial activities which formally result from the reaction of an aldehyde with indole motivated to investigate the reaction of a dialdehyde and indole to give novel structures with potential antibacterial activities.

Methods: Compounds were yielded by chemical synthesis and purified using column chromatography. The antibacterial activity was determined as minimal inhibitory growth activity in cultures of Gram-positive strains of Staphylococcus aureus and Enterococcus species.

Results: Cyclohepta[2,3-b]indoles have been yielded in a one-step reaction procedure with indole substitutions at the cycloheptane central core matching a solution for achieving fused novel cycloalkane indoles with functionalized residues of promising biological activity. So far fused cycloalkane indoles have not been available in a one-step procedure and moreover, core functionalizations have been additional challenges. Various indole substitutions have been done to provide a first set of compounds.

Conclusion: Substituent-dependent effects have been suggested to influence the antibacterial activity and first compounds were identified with specific Staphylococcus activities and Enterococcus species effects towards Enterococcus faecalis as critical pathogens in the hospital with upcoming resistances against standard antibiotics.

Keywords: One-step procedure, fused indole, structure-activity relationships, antibacterial, Staphylococcus aureus, Enterococcus.

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Article Details

Year: 2019
Published on: 18 November, 2019
Page: [833 - 839]
Pages: 7
DOI: 10.2174/1573406415666190208170126
Price: $65

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