Acute Leriche Syndrome in Pancreatic Adenocarcinoma: A Case Report

Author(s): Eftychia Mosa, Stamo Manouvelou, Maria Tolia*, Nikolaos Tsoukalas, Alexandros Ardavanis, Myrsini Stasinopoulou, George Kyrgias, Aggeliki Tavernaraki

Journal Name: Current Medical Imaging
Formerly: Current Medical Imaging Reviews

Volume 16 , Issue 5 , 2020

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Graphical Abstract:


Introduction: Coexistance of pancreatic carcinoma and Leriche syndrome is an extremely rare pathological condition. Leriche syndrome is defined as occlusion of the distal aorta at the bifurcation into the common iliac arteries.

Case Report: We report the case of a 57-year old male patient with a locally advanced pancreatic tumor that during chemotherapy presented Leriche syndrome. Four months after the diagnosis and although the initial staging by MRI had only revealed a few atheromatic lesions of the abdominal aorta, the patient complained about claudication of the legs and hypoesthesia. Angiography with multi-detector computed tomography (MDCTA) was performed using aortography protocol and three-dimensional reconstruction of the images followed, demonstrating the relationship between pancreatic carcinoma and Leriche syndrome.

Conclusion: Review of the literature revealed that acute abdominal thrombosis is rare in cancer patients. To our knowledge, complete occlusion of the aorta in a patient with pancreatic cancer has not been reported yet.

Keywords: Pancreatic cancer, leriche syndrome, chemotherapy, MDCTA, carcinoma, tumor.

Yu JS, Coleman J, Quivey JM. Pancreatic cancer Handbook of evidence based radiation oncology. 2nd ed. New York: Springer 2010.
Poirée S, Monnier-Cholley L, Tubiana JM, Arrivé L. Acute abdominal aortic thrombosis in cancer patients. Abdom Imaging 2004; 29(4): 511-3.
[] [PMID: 15024514]
Schattner A, Klepfish A, Huszar M, Shani A. Two patients with arterial thromboembolism among 311 patients with adenocarcinoma of the pancreas. Am J Med Sci 2002; 324(6): 335-8.
[] [PMID: 12495302]
Dieckmann KP, Gehrckens R. Thrombosis of abdominal aorta during cisplatin-based chemotherapy of testicular seminoma - a case report. BMC Cancer 2009; 9: 459.
[] [PMID: 20028501]
Thomas RH. Hypercoagulability syndromes. Arch Intern Med 2001; 161(20): 2433-9.
[] [PMID: 11700155]
Sun NC, McAfee WM, Hum GJ, Weiner JM. Hemostatic abnormalities in malignancy, a prospective study of one hundred eight patients. Part I. Coagulation studies. Am J Clin Pathol 1979; 71(1): 10-6.
[] [PMID: 420161]
Rickles FR, Levine M, Edwards RL. Hemostatic alterations in cancer patients. Cancer Metastasis Rev 1992; 11(3-4): 237-48.
[] [PMID: 1423816]
Haim N, Lanir N, Hoffman R, Haim A, Tsalik M, Brenner B. Acquired activated protein C resistance is common in cancer patients and is associated with venous thromboembolism. Am J Med 2001; 110(2): 91-6.
[] [PMID: 11165549]
Kakkar AK, DeRuvo N, Chinswangwatanakul V, Tebbutt S, Williamson RC. Extrinsic-pathway activation in cancer with high factor VIIa and tissue factor. Lancet 1995; 346(8981): 1004-5.
[] [PMID: 7475548]
Zhang Y, Deng Y, Luther T, et al. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest 1994; 94(3): 1320-7.
[] [PMID: 7521887]
Carroll VA, Binder BR. The role of the plasminogen activation system in cancer. Semin Thromb Hemost 1999; 25(2): 183-97.
[] [PMID: 10357086]
Karabacak K, Kadan M, Kaya E, et al. Oxaliplatin Induced Digital Ischemia and Necrosis. Case Rep Vasc Med 2015; 2015 248748
[] [PMID: 26064768]
Larsen AC, Frøkjær JB, Fisker RV, et al. Treatment-related frequency of venous thrombosis in lower esophageal, gastro-esophageal and gastric cancer--a clinical prospective study of outcome and prognostic factors. Thromb Res 2015; 135(5): 802-8.
[] [PMID: 25743885]
Dzaye O, Cleator S, Nihoyannopoulos P. Acute coronary artery thrombosis and vasospasm following capecitabine in conjunction with oxaliplatin treatment for cancer. BMJ Case Rep 2014; 2014 bcr2014205567
[] [PMID: 25246465]

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Article Details

Year: 2020
Published on: 29 May, 2020
Page: [622 - 624]
Pages: 3
DOI: 10.2174/1573405615666190206161013
Price: $65

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