Background & Objective: Acute renal failure (AKI) is one of the most important
complications of PCI. Due to delay in creatinine increase, we need specific factors to detect AKI
earlier. The aim of this study is to evaluate the valuable factors by focusing on HFAB-P that can be
predictive for AKI after Percutaneous Coronary Intervention (PCI).
Methods: This prospective study was performed on 95 patients (55 males and 44 females aged
between 49-78 years) under PCI in Golestan and Imam Khomeini hospitals in Ahvaz. Patients were
divided into three groups based on the development of AKI after the procedure: no AKI, severe
AKI (doubling of serum creatinine or needing dialysis) and any type of AKI (increased creatinine ≥
0/3 mg/dl or a 50% increase in the means of 1/5 times serum creatinine). The demographic and
clinical characteristics of the patients, the medical history and the results of the HFABP marker,
GFR, and creatinine before and after PCI were evaluated for all patients.
Results: The progenies showed 6 patients with severe AKI, 17 patients with any type of AKI, and
72 patients without AKI. Diabetes (P = 0.003), hypertension (P = 0.027), gender of patients (P =
0.025) and hospital admission days (P <0.001) were significantly different among the groups.
Patients' age and positive troponin were significantly higher in patients with AKI. HFABP was the
only factor that had significant changes before and after PCI (P <0.001). The cut-off value of
HFABP was 4.69 with 95.6% sensitivity and 84.7% specificity. It has a good negative predictive
value of 98.39% which suggests it to be a good test for the AKI prediction. Glomerular Filtration
Rate (GFR) and creatinine (Cr) were significantly different after PCI (P <0.001).
Conclusion: HFABP can be considered as a predictor for AKI after PCI. Moreover, our study
suggests that evaluating several parameters such as Cr and GFR before and after PCI can predict the
AKI development after PCI.