Relationship Between Level of Heart Type Fatty Acid Binding Protein (Before and after Procedures) with Acute Renal Failure after PCI in Patients Under PCI

Author(s): Habib Haybar*, Ahmad R. Assareh, Mina Mohammadzadeh, Shahla A. Hovyzian

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
Formerly Current Drug Targets - Cardiovascular & Hematological Disorders

Volume 20 , Issue 1 , 2020

Become EABM
Become Reviewer

Graphical Abstract:


Background & Objective: Acute renal failure (AKI) is one of the most important complications of PCI. Due to delay in creatinine increase, we need specific factors to detect AKI earlier. The aim of this study is to evaluate the valuable factors by focusing on HFAB-P that can be predictive for AKI after Percutaneous Coronary Intervention (PCI).

Methods: This prospective study was performed on 95 patients (55 males and 44 females aged between 49-78 years) under PCI in Golestan and Imam Khomeini hospitals in Ahvaz. Patients were divided into three groups based on the development of AKI after the procedure: no AKI, severe AKI (doubling of serum creatinine or needing dialysis) and any type of AKI (increased creatinine ≥ 0/3 mg/dl or a 50% increase in the means of 1/5 times serum creatinine). The demographic and clinical characteristics of the patients, the medical history and the results of the HFABP marker, GFR, and creatinine before and after PCI were evaluated for all patients.

Results: The progenies showed 6 patients with severe AKI, 17 patients with any type of AKI, and 72 patients without AKI. Diabetes (P = 0.003), hypertension (P = 0.027), gender of patients (P = 0.025) and hospital admission days (P <0.001) were significantly different among the groups. Patients' age and positive troponin were significantly higher in patients with AKI. HFABP was the only factor that had significant changes before and after PCI (P <0.001). The cut-off value of HFABP was 4.69 with 95.6% sensitivity and 84.7% specificity. It has a good negative predictive value of 98.39% which suggests it to be a good test for the AKI prediction. Glomerular Filtration Rate (GFR) and creatinine (Cr) were significantly different after PCI (P <0.001).

Conclusion: HFABP can be considered as a predictor for AKI after PCI. Moreover, our study suggests that evaluating several parameters such as Cr and GFR before and after PCI can predict the AKI development after PCI.

Keywords: Acute kidney injuries, percutaneous coronary intervention, H-FABP protein, creatinine, glomerular filtration rate, myocardial infarction.

Haybar, H.; Shahrabi, S.; Deris Zayeri, Z.; Pezeshki, S. Strategies to increase cardioprotection through cardioprotective chemokines in chemotherapy-induced cardiotoxicity. Int. J. Cardiol., 2018, 269, 276-282.
[] [PMID: 30054148]
Lenihan, C.R.; Montez-Rath, M.E.; Mora Mangano, C.T.; Chertow, G.M.; Winkelmayer, W.C. Trends in acute kidney injury, associated use of dialysis, and mortality after cardiac surgery, 1999 to 2008. Ann. Thorac. Surg., 2013, 95(1), 20-28.
[] [PMID: 23272825]
Tsai, T.T.; Patel, U.D.; Chang, T.I.; Kennedy, K.F.; Masoudi, F.A.; Matheny, M.E.; Kosiborod, M.; Amin, A.P.; Messenger, J.C.; Rumsfeld, J.S.; Spertus, J.A. Contemporary incidence, predictors, and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions: insights from the NCDR Cath-PCI registry. JACC Cardiovasc. Interv., 2014, 7(1), 1-9.
[] [PMID: 24456715]
Mehran, R.; Aymong, E.D.; Nikolsky, E.; Lasic, Z.; Iakovou, I.; Fahy, M.; Mintz, G.S.; Lansky, A.J.; Moses, J.W.; Stone, G.W.; Leon, M.B.; Dangas, G. A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: Development and initial validation. J. Am. Coll. Cardiol., 2004, 44(7), 1393-1399.
[] [PMID: 15464318]
Briguori, C.; Visconti, G.; Focaccio, A.; Airoldi, F.; Valgimigli, M.; Sangiorgi, G.M.; Golia, B.; Ricciardelli, B.; Condorelli, G. REMEDIAL II Investigators. Renal insufficiency after contrast media administration trial II (REMEDIAL II). Circulation, 2011, 124(11), 1260-1269.
[] [PMID: 21844075]
Coca, S.G.; Yusuf, B.; Shlipak, M.G.; Garg, A.X.; Parikh, C.R. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. Am. J. Kidney Dis., 2009, 53(6), 961-973.
[] [PMID: 19346042]
Hobson, C.E.; Yavas, S.; Segal, M.S.; Schold, J.D.; Tribble, C.G.; Layon, A.J.; Bihorac, A. Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery. Circulation, 2009, 119(18), 2444-2453.
[] [PMID: 19398670]
Parikh, C.R.; Coca, S.G.; Thiessen-Philbrook, H.; Shlipak, M.G.; Koyner, J.L.; Wang, Z.; Edelstein, C.L.; Devarajan, P.; Patel, U.D.; Zappitelli, M.; Krawczeski, C.D.; Passik, C.S.; Swaminathan, M.; Garg, A.X. TRIBE-AKI Consortium. Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J. Am. Soc. Nephrol., 2011, 22(9), 1748-1757.
[] [PMID: 21836143]
Melnikov, V.Y.; Faubel, S.; Siegmund, B.; Lucia, M.S.; Ljubanovic, D.; Edelstein, C.L. Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice. J. Clin. Invest., 2002, 110(8), 1083-1091.
[] [PMID: 12393844]
Hornik, C.P.; Krawczeski, C.D.; Zappitelli, M.; Hong, K.; Thiessen-Philbrook, H.; Devarajan, P.; Parikh, C.R.; Patel, U.D. TRIBE-AKI Consortium. Serum brain natriuretic peptide and risk of acute kidney injury after cardiac operations in children. Ann. Thorac. Surg., 2014, 97(6), 2142-2147.
[] [PMID: 24725832]
Testani, J.M.; Damman, K.; Brisco, M.A.; Chen, S.; Laur, O.; Kula, A.J.; Tang, W.H.; Parikh, C. A combined-biomarker approach to clinical phenotyping renal dysfunction in heart failure. J. Card. Fail., 2014, 20(12), 912-919.
[] [PMID: 25152498]
Smathers, R.L.; Petersen, D.R. The human fatty acid-binding protein family: Evolutionary divergences and functions. Hum. Genomics, 2011, 5(3), 170-191.
[] [PMID: 21504868]
Maatman, R.G.; Van Kuppevelt, T.H.; Veerkamp, J.H. Two types of fatty acid-binding protein in human kidney. Isolation, characterization and localization. Biochem. J., 1991, 273(Pt 3), 759-766.
[] [PMID: 1996972]
Storch, J.; Thumser, A.E. The fatty acid transport function of fatty acid-binding proteins. Biochimica et Biophysica Acta (BBA)-. Mol. Cell Biol. Lip., 2000, 1486(1), 28-44.
Suzuki, K.; Sawa, Y.; Kadoba, K.; Takahashi, T.; Ichikawa, H.; Kagisaki, K.; Ohata, T.; Matsuda, H. Early detection of cardiac damage with heart fatty acid-binding protein after cardiac operations. Ann. Thorac. Surg., 1998, 65(1), 54-58.
[] [PMID: 9456095]
Liebetrau, C.; Nef, H.M.; Dörr, O.; Gaede, L.; Hoffmann, J.; Hahnel, A.; Rolf, A.; Troidl, C.; Lackner, K.J.; Keller, T.; Hamm, C.W.; Möllmann, H. Release kinetics of early ischaemic biomarkers in a clinical model of acute myocardial infarction. Heart, 2014, 100(8), 652-657.
[] [PMID: 24488609]
McCann, C.J.; Glover, B.M.; Menown, I.B.; Moore, M.J.; McEneny, J.; Owens, C.G.; Smith, B.; Sharpe, P.C.; Young, I.S.; Adgey, J.A. Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T. Eur. Heart J., 2008, 29(23), 2843-2850.
[] [PMID: 18682444]
Parikh, C.R.; Thiessen-Philbrook, H.; Garg, A.X.; Kadiyala, D.; Shlipak, M.G.; Koyner, J.L.; Edelstein, C.L.; Devarajan, P.; Patel, U.D.; Zappitelli, M.; Krawczeski, C.D.; Passik, C.S.; Coca, S.G. TRIBE-AKI Consortium. Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. Clin. J. Am. Soc. Nephrol., 2013, 8(7), 1079-1088.
[] [PMID: 23599408]
Wi, J.; Ko, Y-G.; Kim, J-S.; Kim, B-K.; Choi, D.; Ha, J-W.; Hong, M.K.; Jang, Y. Impact of contrast-induced acute kidney injury with transient or persistent renal dysfunction on long-term outcomes of patients with acute myocardial infarction undergoing percutaneous coronary intervention. Heart, 2011, 97(21), 1753-1757.
[] [PMID: 21602521]
Manabe, K.; Kamihata, H.; Motohiro, M.; Senoo, T.; Yoshida, S.; Iwasaka, T. Urinary liver-type fatty acid-binding protein level as a predictive biomarker of contrast-induced acute kidney injury. Eur. J. Clin. Invest., 2012, 42(5), 557-563.
[] [PMID: 22070248]
Malyszko, J. Biomarkers of acute kidney injury in different clinical settings: A time to change the paradigm? Kidney Blood Press. Res., 2010, 33(5), 368-382.
[] [PMID: 20924195]
Doi, K.; Noiri, E.; Sugaya, T. Urinary L-type fatty acid-binding protein as a new renal biomarker in critical care. Curr. Opin. Crit. Care, 2010, 16(6), 545-549.
[] [PMID: 20736829]
Schaub, J.A.; Garg, A.X.; Coca, S.G.; Testani, J.M.; Shlipak, M.G.; Eikelboom, J.; Kavsak, P.; McArthur, E.; Shortt, C.; Whitlock, R.; Parikh, C.R. TRIBE-AKI Consortium. Perioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery. Kidney Int., 2015, 88(3), 576-583.
[] [PMID: 25830762]
Oezkur, M.; Gorski, A.; Peltz, J.; Wagner, M.; Lazariotou, M.; Schimmer, C.; Heuschmann, P.U.; Leyh, R.G. Preoperative serum h-FABP concentration is associated with postoperative incidence of acute kidney injury in patients undergoing cardiac surgery. BMC Cardiovasc. Disord., 2014, 14(1), 117.
[] [PMID: 25212385]

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2020
Published on: 26 February, 2020
Page: [41 - 46]
Pages: 6
DOI: 10.2174/1871529X19666190206153012
Price: $65

Article Metrics

PDF: 20