Background: Salivary Adenoid Cystic Carcinoma (ACC) is a malignant tumor located
at oral and maxillofacial regions, and its conventional treatments are surgery, chemotherapy and
radiotherapy. However, its poor survival rates and prognosis resulting from the molecular mechanisms
underlying the carcinogenesis remain obscure. To date, there are insufficient reviews to
summarize the genes and molecular pathways for ACC. Therefore, it is required for us to highlight
the main oncogenes, tumor suppressor genes and genetic signal transduction pathways associated
with ACC in this review.
Materials and Methods: A literature review based on PubMed for the genetic characteristics and
molecular transduction pathways for ACC was conducted. Ninety articles were selected as references
using the search terms or keywords such as “genes, molecular pathways, salivary adenoid
cystic carcinoma or ACC”.
Results: We have briefly described histopathology, current treatments and main clinical features
in ACC. Besides, we have also elaborated the associated genes and pathways in this review according
to the searched articles in recent years.
Conclusion: We have summarized vital genes and proteins targeting or mechanism-based on proliferation,
apoptosis, invasion and metastasis. Although there are few kinds of research on ACC
currently exist, we expect that better detailed genetic studies would pave the way for promising
advancement in our understanding of the molecular biology and pathogenesis mechanisms underlying