Background: Gastric cancer is a major malignancy that has high incidence rates worldwide.
Approximately 30% of patients with gastric cancer have progressed into advanced stages at
the time of diagnosis. Chemotherapy is the standard-of-care for most advanced gastric cancer and
elicits variable responses among patients. Personalized chemotherapy based on genetic information
of individual patients with gastric cancer has gained increasing attention among oncologists for
guiding chemotherapeutic regimens.
Methods: This review summarizes recent progress of individualized chemotherapy in gastric cancer
guided by pharmacogenomics. Variable medical research search engines, such as PubMed, Google
Scholar, SpringerLink and ScienceDirect, were used to retrieve related literature. Only peerreviewed
journal articles were selected for further analyses.
Results and Conclusion: The efficiency of chemotherapy in patients with gastric cancer is not only
determined by chemotherapeutic drugs but is also directly and indirectly influenced by functionally
correlative genes. Individual gene alteration or polymorphism remarkably affects patients’ responses
to particular chemotherapy. Most studies have focused on the influence of single-gene alteration on
a selected drug, and only a few works explored the interaction between therapeutics and a panel of
genes. Individualized chemotherapy regimens guided by a genetic survey of a multiple-gene panel
are expected to remarkably improve the treatment efficacy in patients with advanced gastric cancer
and may become the new standard for personalizing chemotherapy for gastric cancer in the near