Analysis of Safety Outcomes in Chronic Hepatitis C Patients using Interferon-free Treatment: A Systematic Review of Case Reports

Author(s): Vinicius Lins Ferreira*, Leticia Paula Leonart, Ana Maria Della Rocca, Roberto Pontarolo

Journal Name: Current Drug Therapy

Volume 14 , Issue 3 , 2019

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Graphical Abstract:


Background: Second generation direct acting-antivirals are safe and effective treatments for chronic hepatitis C patients.

Objective: We aimed to conduct a systematic review of case reports and case series to evaluate the safety of the drugs, highlighting a compilation of AE not previously reported in other reviews.

Methods: The search was performed in four electronic databases and included only case reports and case series that evaluated interferon-free therapies and provided safety outcomes.

Results: Initially 1,235 records were retrieved, and after screening 30 studies were included in the analysis (23 case reports and 7 case series). A total of 39 patients were included, receiving eight different interferon-free treatments. Nineteen patients discontinued treatment (only 8 of these achieved treatment response). Other 19 patients achieved SVR without discontinuation. Rare adverse events were observed, including breast hypertrophy, retinopathy and drug-induced infection. Some patients were in an advanced stage of the disease, and were therefore unable to withstand treatment due to the appearance of complications.

Conclusion: In this sense, it is important to monitor the use of these drugs that can favor the appearance of serious AE. (PROSPERO registration number CRD42016051680).

Keywords: Interferon-free, hepatitis C, case report, systematic review, case series, treatment.

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Article Details

Year: 2019
Published on: 22 October, 2019
Page: [210 - 219]
Pages: 10
DOI: 10.2174/1574885514666190130162547
Price: $65

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