Allopurinol and Loss of Consciousness in a 78-old Year Man Suffering from Gout

Author(s): Mahnaz Arian, Mina AkbariRad*, Ahmad Bagheri Moghaddam, Abdollah Firoozi, Mohammad Jami

Journal Name: Infectious Disorders - Drug Targets
(Formerly Current Drug Targets - Infectious Disorders)

Volume 20 , Issue 2 , 2020

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Graphical Abstract:


Abstract:

Allopurinol is an FDA -Approved xanthine oxidase inhibitor, which is effective in the treatment of gout, hyperuricemia and uremic kidney stones in patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine into uric acid, and therefore its inhibition results in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction.

Case Presentation: This report represents a case of drug-induced meningitis of a senile man who ended up in the ICU due to the remarkably reduced state of consciousness.

Keywords: Allopurinol, drug-induced meningitis, bacterial meningitis, consciousnes, gout, hyperuricemia.

[1]
Brunton, L.L. Goodman Gilman’s the pharmacological basis of therapeutics; McGraw Hill Medical: New York, 2018.
[2]
Trevor, A.J.; Katzung, B.G.; Masters, S.B. Katzung Trevor’s pharmacology: examination board review; McGraw Hill Medical: New York. , 2008. viii, p. 631.
[3]
Qurie, A.; Musa, R. Allopurinol; StatPearls: Treasure Island, FL, 2018.
[4]
Duchene, D.A.; Smith, C.P.; Goldfarb, R.A. Allopurinol induced meningitis. J. Urol., 2000, 164(6), 2028.
[http://dx.doi.org/10.1016/S0022-5347(05)66950-9] [PMID: 11061913]
[5]
Greenberg, L.E.; Nguyen, T.; Miller, S.M. Suspected allopurinol-induced aseptic meningitis. Pharmacotherapy, 2001, 21(8), 1007-1009.
[http://dx.doi.org/10.1592/phco.21.11.1007.34526] [PMID: 11718488]
[6]
Christen, S.; Bifrare, Y.D.; Siegenthaler, C.; Leib, S.L.; Täuber, M.G. Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis. Brain Res., 2001, 900(2), 244-251.
[http://dx.doi.org/10.1016/S0006-8993(01)02311-3] [PMID: 11334804]


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Article Details

VOLUME: 20
ISSUE: 2
Year: 2020
Page: [253 - 256]
Pages: 4
DOI: 10.2174/1871526519666190128102039
Price: $65

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