Title:Nanocapsules for Drug Delivery: An Updated Review of the Last Decade
VOLUME: 12 ISSUE: 4
Author(s):Nazlı Erdoğar*, Safiye Akkın and Erem Bilensoy
Affiliation:Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Sihhiye-Ankara, Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Sihhiye-Ankara, Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Sihhiye-Ankara
Keywords:Drug delivery, mucosal, nanocapsule, oral, parenteral, topical.
Abstract:Background: For the past few decades, there has been considerable research interest in drug
delivery strategies using nanoparticulate systems as carriers for a wide range of active pharmaceutical
ingredients.
Objective: It is known that nanoparticulate drug delivery systems comprise a wide variety of dosage
forms including nanospheres, micelles, solid lipid nanoparticles, nanoliposomes, dendrimers, magnetic
nanoparticles, and nanocapsules.
Methods: This review describes nanocapsule preparation techniques and their applications for the
treatment of several diseases using patents and examples from the literature.
Results: Nanocapsules are vesicular systems consisting of an inner liquid core (aqueous/oily) surrounded
by a polymeric wall that has immense potential as drug carriers because of the many advantages
like improving poor aqueous solubility, stabilizing drugs by protecting the molecule from the
environment, providing the desired pharmacokinetic profile, allowing controlled release, as well as
facilitating oral administration.
Conclusion: The present study discusses and summarizes patents related to preparation methods of and
recent studies from the last 10 years on nanocapsules as drug delivery systems.
