Flavonoid-Enriched Extract from Desert Plant Warionia saharae Improves Glucose and Cholesterol Levels in Diabetic Rats

Author(s): Mohammed Ajebli, Mohamed Eddouks*

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 17 , Issue 1 , 2019

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Graphical Abstract:


Background and Objective: Warionia saharae Benth and Coss, is a medicinal plant used for its anti-diabetic properties in Morocco. This study was designed to examine the effect of the Flavonoid- Enriched Extract (FEE) obtained from Warionia saharae (W. saharae) on glucose and lipid metabolism in normal and streptozotocin (STZ)-induced diabetic rats.

Methods: Acute (6 h) and sub-chronic (15 days) oral administration of FEE (10 mg/kg) was used to assess the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and in vitro antioxidant activity of FEE were carried out in this study.

Results: Results indicated that FEE was able to exert antihyperglycemic activity. Additionally, FEE improved histopathological status of liver and pancreas in diabetic rats and possessed antioxidant activity.

Conclusion: In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats.

Keywords: Antioxidant, diabetes, flavonoid-enriched extract, histopathology, lipid profile, Warionia saharae.

Ajebli, M.; Eddouks, M. The promising role of plant tannins as bioactive antidiabetic agents. Curr. Med. Chem., 2018.
Testa, R.; Bonfigli, A.R.; Genovese, S.; De Nigris, V.; Ceriello, A. The possible role of flavonoids in the prevention of diabetic complications. Nutrients, 2016, 8, 1-13.
Krych, J.; Gebicka, L. Catalase is inhibited by flavonoids. Int. J. Biol. Macromol., 2013, 58, 148-153.
Zhang, X.; Huang, H.; Zhao, X. Effects of flavonoids-rich Chinese bayberry (Myrica rubra Sieb. et Zucc.) pulp extracts on glucose consumption in human HepG2 cells. J. Funct. Foods, 2015, 14, 144-153.
Zhang, J.; Wu, Y.; Zhao, X. Chemopreventive effect of flavonoids from Ougan (Citrus reticulata cv. Suavissima) fruit against cancer cell proliferation and migration. J. Funct. Foods, 2014, 10, 511-519.
Bahadoran, Z.; Mirmiran, P.; Azizi, F. Dietary polyphenols as potential nutraceuticals in management of diabetes: A review. J. Diabetes Metab. Disord., 2013, 12, 43.
Johnston, K.; Sharp, P.; Clifford, M.; Morgan, L. Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells. FEBS Lett., 2005, 579, 1653-1657.
Jung, U.J.; Lee, M.K.; Jeong, K.S.; Choi, M.S. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepaticglucose-regulating enzymes in C57BL/KsJ-db/db mice. J. Nutr., 2004, 134, 2499-2503.
Yeon, J.Y.; Bae, Y.J.; Kim, E.Y. Association between flavonoid intake and diabetes risk among the Koreans. Clin. Chim. Acta, 2015, 439, 225-230.
Lewalle, L. Warionia saharae Cosson. Al Biruniya, 1986, 3, 77-78.
Eddouks, M.; Ajebli, M.; Hebi, M. Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco. J. Ethnopharmacol., 2017, 198, 516-530.
Evans, W.C. Trease and Evans Pharmacognosy, 14th ed; Singapore: Harcourt Brace and company, Asia Pvt. Ltd. , 1997, pp. 12-68.
Louli, V.; Ragoussis, N.; Magoulas, K. Recovery of phenolic antioxidants from wine industry by-products. Bioresour. Technol., 2004, 92, 201.
Hebi, M.; Farid, O.; Ajebli, M.; Eddouks, M. Potent antihyperglycemic and hypoglycemic effect of Tamarix articulata Vahl. in normal and streptozotocin-induced diabetic rats. Biomed. Pharmacother., 2017, 87, 230-239.
Ajebli, M.; Eddouks, M. Buxus sempervirens L improves streptozotocin-induced diabetes mellitus in rats. Cardiovasc. Hematol. Disord. Drug Targets, 2017, 17, 142-152.
Ajebli, M.; Eddouks, M. Pharmacological and phytochemical study of Mentha suaveolens Ehrh in normal and streptozotocin-induced diabetic rats. Nat. Prod. J., 2018.
Ajebli, M.; Eddouks, M. Buxus sempervirens L. improves lipid profile in diabetic rats. Cardiovasc. Hematol. Disord. Drug Targets, 2018, 18, 239-246.
Ajebli, M.; El Ouady, F.; Eddouks, M. Study of antihyperglycemic, antihyperlipidemic and antioxidant activities of tannins extracted from Warionia saharae Benth. & Coss. Endocr. Metab. Immune Disord. Drug Targets, 2018.
Hebi, M.; Eddouks, M. Glucose lowering activity of the aqueous extract of Warionia saharae in normal and diabetic rats. Cardiovasc. Hematol. Agents Med. Chem., 2018, 16, 66-72.
Ramesh, B.K.; Maddirala, D.R.; Vinay, K.K.; Shaik, S.F.; Tiruvenkata, K.E.G.; Swapna, S.; Ramesh, B.; Rao, C.A. Antihyperglycemic and antihyperlipidemic activities of methanol: Water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin-induced diabetic rats. Food Chem. Toxicol., 2010, 48, 1078-1084.
Yuan, M.; Konstantopoulos, N.; Lee, J. Reversal of obesity and diet induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science, 2001, 293, 1673-1677.
Imran, A.; Butt, M.S.; Arshad, M.S.; Arshad, M.U.; Saeed, F.; Sohaib, M.; Munir, R. Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders. Lipids Health Dis., 2018, 17
Evans, J.L.; Goldfine, I.D.; Maddux, B.A.; Grodsky, G.M. Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction? Diabetes, 2003, 52, 1-8.
Kregel, K.C.; Zhang, H.J. An integrated view of oxidative stress in aging: Basic mechanisms, functional effects, and pathological considerations. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007, 292, R18-R36.
Ferreira, J.F.S.; Luthria, D.L.; Sasaki, T.; Heyerick, A. Flavonoids from artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. Molecules, 2010, 15313570
Pereira, M.A.; Kottke, T.E.; Jordan, C.; O’Connor, P.J.; Pronk, N.P.; Carreon, R. Preventing and managing cardiometabolic risk: The logic for intervention. Int. J. Environ. Res. Public Health, 2009, 6256884
Ceballos-Coronel, M.L. Nutraceuticals in Diabetes Management; In: Yashwant, P. Eds., Handbook of nutraceuticals, volume 1.. Taylor and Francis Group, LLC: New York, 2010, pp. 207-215.

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Article Details

Year: 2019
Published on: 12 September, 2019
Page: [28 - 39]
Pages: 12
DOI: 10.2174/1871525717666190121143934

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