Rhaponticin is a stilbenoid glucoside compound, found in medicinal plant of rhubarb
rhizomes. Rhapontigenin (RHAG), the stilbene aglycone metabolite of rhaponticin, has
shown various biological activities including anticancer activities to act a potential human cytochrome
P450 inhibitor, antihyperlipidemic effect, anti-allergic action, antioxidant and antibacterial
activities. Moreover, it was reported to scavenge intracellular Reactive Oxygen Species
(ROS), the 1,1-Diphenyl-2-Picrylliydrazyl (DPPH) radical, and Hydrogen Peroxide
(H2O2). Meanwhile, RHAG exhibited the inhibitory activity for the synthesis of DNA, RNA
and protein, and also presented the capacity of inducing morphological changes and apoptosis
of C. albicans. Here, the structure, pharmacokinetics, pharmacological effects as well as underlying
mechanisms of rhaponticin and its metabolite, RHAG, have been extensively reviewed.
This review will provide a certain reference value for developing the therapeutic drug
of rhaponticin or RHAG.