Metabolism of Rhaponticin and Activities of its Metabolite, Rhapontigenin: A Review

Author(s): Dan Chen, Jing-Ru Liu, Yanjin Cheng, Hua Cheng, Ping He, Yang Sun*.

Journal Name: Current Medicinal Chemistry

Volume 27 , Issue 19 , 2020

  Journal Home
Translate in Chinese
Become EABM
Become Reviewer


Rhaponticin is a stilbenoid glucoside compound, found in medicinal plant of rhubarb rhizomes. Rhapontigenin (RHAG), the stilbene aglycone metabolite of rhaponticin, has shown various biological activities including anticancer activities to act a potential human cytochrome P450 inhibitor, antihyperlipidemic effect, anti-allergic action, antioxidant and antibacterial activities. Moreover, it was reported to scavenge intracellular Reactive Oxygen Species (ROS), the 1,1-Diphenyl-2-Picrylliydrazyl (DPPH) radical, and Hydrogen Peroxide (H2O2). Meanwhile, RHAG exhibited the inhibitory activity for the synthesis of DNA, RNA and protein, and also presented the capacity of inducing morphological changes and apoptosis of C. albicans. Here, the structure, pharmacokinetics, pharmacological effects as well as underlying mechanisms of rhaponticin and its metabolite, RHAG, have been extensively reviewed. This review will provide a certain reference value for developing the therapeutic drug of rhaponticin or RHAG.

Keywords: Metabolism, Pharmacokinetics, Cardiovascular disease, Cancer, Rhaponticin, Rhapontigenin.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2020
Page: [3168 - 3186]
Pages: 19
DOI: 10.2174/0929867326666190121143252
Price: $65

Article Metrics

PDF: 11