Title:Noncoding Rnas Emerging as Novel Biomarkers in Pancreatic Cancer
VOLUME: 24 ISSUE: 39
Author(s):Ingrid Garajová*, Rita Balsano, Chiara Tommasi and Elisa Giovannetti
Affiliation:Medical Oncology Unit, University Hospital of Parma, Parma, Medical Oncology Unit, University Hospital of Parma, Parma, Medical Oncology Unit, University Hospital of Parma, Parma, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam
Keywords:Noncoding RNA, pancreatic cancer, biomarker, miRNAs, chemotherapy, epigenetic regulation.
Abstract:Noncoding RNAs play important regulatory roles in diverse biological processes and their misregulation
might lead to different diseases, including cancer. Previous studies have reported the evolving role of miRNAs
as new potential biomarkers in cancer diagnosis, prognosis, as well as predictive biomarkers of chemotherapy
response or therapeutic targets. In this review, we outline the involvement of noncoding RNA in pancreatic
cancer, providing an overview of known miRNAs in its diagnosis, prognosis and chemoresistance. In addition,
we discuss the influence of non-coding RNAs in the metastatic behavior of pancreatic cancer, as well as the role
of diet in epigenetic regulation of non-coding RNAs in cancer, which can, in turn, lead the development of new
prevention’s techniques or novel targets for cancer therapy.
