Objective: A number of natural polymer-based drug delivery systems targeting
the colon are reported for different applications. Most of the research is based on the class
of natural polymers such as polysaccharides. This study compares the anti-inflammatory
effect of different polysaccharide based tablets on IBD when a drug carrier is targeted to
the colon as matrix and coated systems.
Methods: The TNBS induced IBD Wistar rats were used as a model for the study. The microscopic
and macroscopic parameters were studied in detail. Almost all the important IBD
parameters were reported in this work.
Results: The results demonstrated that the polysaccharides are efficient in carrying the
drugs to the colon. Reduction in the level of ulcer index (UI), Myeloperoxidase (MPO),
and Malondialdehyde MDA, confirmed the inhibitory activity on the development of Reactive
oxygen species (ROS). The increased level of Tumor necrosis factor (TNFα) an expression
of colonic inducible nitric oxide synthase (iNOS) was lowered in treatments as
compared to TNBS control.
Conclusion: The different polymer-based mesalamine (DPBM) confirmed the efficient anti-
inflammatory activity on IBD induced rats. The increased level of glutathione (GSH),
and superoxide dismutase (SOD) also confirmed the effective anti-inflammatory effect. A
significant decrease in the ulcer score and ulcer area was reported. The investigation revealed
that chitosan is superior to pectin in IBD treatment likewise polysaccharide-based
matrix systems are superior to the coated system.