The Effects of Traditional Chinese Medicine on Inflammatory Cytokines in Diabetic Nephropathy: The Progress in the Past Decades
Pp. 108-134 (27)
Xiang Tu, Yuan Ping Deng, Ming Chen, James B. Jordan and Sen Zhong
Current research has revealed that inflammation as the cardinal
pathophysiological mechanism in the development and progression of diabetic
nephropathy (DN). Diverse inflammatory cytokines interact with each other and
together with other mechanisms; result in the progression of DN. It is now widely
accepted that many inflammatory cytokines, such as transforming growth factor
(TGF)-β1, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1,
interleukin (IL)-1, IL-18, etc. are involved in the pathogenesis and development of DN.
Published articles reported that a large number of single Traditional Chinese Medicine
(TCM) and their extracts could confer benefits to DN by regulating inflammatory
cytokines; such as Astragalus, Danshen Root, Szechuan Lovage Rhizome, Kudzuvine
Root, Common Threewingnut Root, etc. TCM formulae also could regulate
inflammatory cytokines in DN; such as Buyang Huanwu Decoction, Fufang Danshen
Diwan, Bushen Tongluo Formular, etc. This is usually associated with improved
kidney histomorphology, proteinuria and renal function parameters in DN. Although
some researches concerning TCM for inflammatory cytokines in DN are in-depth, most
researches, if not all, are still very superficial. The signaling pathways and underlying
mechanisms of TCM affecting inflammatory cytokines remain unclear. Although there
are many shortcomings in this field, it is still fortunate that the experimental renobenefits
of TCM can be translated for human into clinical treatment. This indicates new,
effective and promising therapeutic drugs.
Diabetic nephropathy, Diabetes Review, Inflammatory Cytokines,
TCM Formulae, Traditional Chinese Medicine.
National Traditional Chinese Medicine Clinical Research Base for Diabetes Mellitus/Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China.