Title:Interleukin-17A: A Potential Therapeutic Target in Chronic Lung Diseases
VOLUME: 19 ISSUE: 7
Author(s):Sadiya Bi Shaikh, Ashwini Prabhu and Yashodhar Prabhakar Bhandary*
Affiliation:Cell and Molecular Biology Department, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore -575018, Karnataka, Cell and Molecular Biology Department, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore -575018, Karnataka, Cell and Molecular Biology Department, Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore -575018, Karnataka
Keywords:IL-17A, lung diseases, inflammation, cytokine, immune response, cell injury.
Abstract:
Background: Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has gained a lot
of attention because of its involvement in respiratory diseases. Interleukin-17 cytokine family includes
six members, out of which, IL-17A participates towards the immune responses in allergy and
inflammation. It also modulates the progression of respiratory disorders.
Objective: The present review is an insight into the involvement and contributions of the proinflammatory
cytokine IL-17A in chronic respiratory diseases like Idiopathic Pulmonary Fibrosis
(IPF), Chronic Obstructive Pulmonary Distress (COPD), asthma, pneumonia, obliterative bronchiolitis,
lung cancer and many others.
Conclusion: IL-17A is a major regulator of inflammatory responses. In all the mentioned diseases, IL-
17A plays a prime role in inducing the diseases, whereas the lack of this pro-inflammatory cytokine
reduces the severity of respective respiratory diseases. Thereby, this review suggests IL-17A as an
instrumental target in chronic respiratory diseases.