Interleukin-17A: A Potential Therapeutic Target in Chronic Lung Diseases

Author(s): Sadiya Bi Shaikh, Ashwini Prabhu, Yashodhar Prabhakar Bhandary*

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 19 , Issue 7 , 2019

DOI : 10.2174/1871530319666190116115226

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Graphical Abstract:


Abstract:

Background: Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has gained a lot of attention because of its involvement in respiratory diseases. Interleukin-17 cytokine family includes six members, out of which, IL-17A participates towards the immune responses in allergy and inflammation. It also modulates the progression of respiratory disorders.

Objective: The present review is an insight into the involvement and contributions of the proinflammatory cytokine IL-17A in chronic respiratory diseases like Idiopathic Pulmonary Fibrosis (IPF), Chronic Obstructive Pulmonary Distress (COPD), asthma, pneumonia, obliterative bronchiolitis, lung cancer and many others.

Conclusion: IL-17A is a major regulator of inflammatory responses. In all the mentioned diseases, IL- 17A plays a prime role in inducing the diseases, whereas the lack of this pro-inflammatory cytokine reduces the severity of respective respiratory diseases. Thereby, this review suggests IL-17A as an instrumental target in chronic respiratory diseases.

Keywords: IL-17A, lung diseases, inflammation, cytokine, immune response, cell injury.

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VOLUME: 19
ISSUE: 7
Year: 2019
Page: [921 - 928]
Pages: 8
DOI: 10.2174/1871530319666190116115226
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