Catalyst-Free Glycerol Promoted Green Synthesis of 2-amino-1,8- naphthyridine -3-carbonitriles and 2-amino-3-quinolinecarbonitriles

Author(s): Km Neha Shivhare, Anushree Srivastava, Ibadur Rahman Siddiqui*

Journal Name: Current Green Chemistry

Volume 6 , Issue 1 , 2019

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Graphical Abstract:


We describe herein the use of glycerol as an efficient and sustainable approach for the synthesis of 2-amino-1, 8-naphthyridine-3-carbonitriles and 2-amino-3-quinolinecarbonitriles. The catalyst- free reactions occur straightforwardly using biodegradable and non-hazardous solvent. It is a strategy to address mounting environmental concerns with current approach includes the use of environmentally benign solvent, simple workup procedure, economic viability, shorter reaction time and providing good to excellent yield.

Keywords: Glycerol, naphthyridines, quinolines, biocatalyst, bio-renewable, eco-compatible.

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Article Details

Year: 2019
Published on: 18 April, 2019
Page: [62 - 68]
Pages: 7
DOI: 10.2174/2452273203666190114145322

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