Title:From Target Identification to Drug Development in Space: Using the Microgravity Assist
VOLUME: 17 ISSUE: 1
Author(s): Martin Braddock*
Affiliation:Sherwood Observatory, Mansfield and Sutton Astronomical Society, Coxmoor Road, Sutton-in-Ashfield, Nottinghamshire, NG17 5LF
Keywords:Microgravity, target identification, target validation, drug development, protein crystallization, protein crystals.
Abstract:The unique nature of microgravity encountered in space provides an opportunity for drug
discovery and development that cannot be replicated on Earth. From the production of superior protein
crystals to the identification and validation of new drug targets to microarray analyses of transcripts
attenuated by microgravity, there are numerous examples which demonstrate the benefit of exploiting
the space environment. Moreover, studies conducted on Space Shuttle missions, the International
Space Station and other craft have had a direct benefit for drug development programmes such as those
directed against reducing bone and muscle loss or increasing bone formation. This review will highlight
advances made in both drug discovery and development and offer some future insight into how
drug discovery and associated technologies may be further advanced using the microgravity assist.