Colorectal cancer (CRC) is the leading cause of cancer death worldwide and its incidence is increasing.
In most patients with CRC, the PI3K/AKT signaling axis is over-activated. Regulatory oncogenic or tumor suppressor
microRNAs (miRNAs) for PI3K/AKT signaling regulate cell proliferation, migration, invasion, angiogenesis,
as well as resistance to chemo-/radio-therapy in colorectal cancer tumor tissues. Thus, regulatory miRNAs
of PI3K/AKT/mTOR signaling represent novel biomarkers for new patient diagnosis and obtaining clinically
invaluable information from post-treatment CRC patients for improving therapeutic strategies. This review summarizes
the current knowledge of miRNAs’ regulatory roles of PI3K/AKT signaling in CRC pathogenesis.