The Phosphatidylinositol 3-kinase/AKT/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) pathway
has a critical regulatory role in cell biology including translation, transcription, and autophagy. Dysregulation
of this pathway is involved in the pathogenesis, development, and prognosis of esophageal cancer that has been
assessed in the recent years and its potential as a target in therapy. This report summarizes the current knowledge
about PI3K/AKT/mTOR pathway and its cross-talk with a focus on the value of targeting this pathway as a potential
therapeutic target in the treatment of esophageal cancer.
Keywords: PI3K/AKT/mTOR pathway, microRNAs, esophageal cancer, rapamycin, translation, transcription.
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