Background: Anti-reflux formulation is one of the popular formulations across the globe
in the pharmaceutical industry used specifically for the management of gastro-oesophageal reflux
disease. But, this formulation is less explored with respect to research. Anti-reflux formulation has
challenges to show its antacid functionality, which could have synergies in the management of refluxes
in gastro-oesophageal reflux disease. Alkalizing agents act as antacid and improve the acid
neutralization capacity in the anti-reflux formulation, and can be used appropriately as they affect
raft strength beyond certain (optimum) limits.
Objective: The objective of this work is to investigate the significance of alkalizing agent in sodium
alginate based on oral liquid anti-reflux suspension for the management of Gastro-oesophageal
Reflux Disease (GERD).
Methods: In the present study, the formulation was prepared using sodium alginate along with different
alkalizing agents like calcium carbonate and sodium bicarbonate at different levels. The formulation
was further studied for in-vitro characterization like pH, viscosity, Acid Neutralization
Capacity (ANC), thickness, formation speed, flotation, and raft strength.
Results: The formulation with a higher level of calcium carbonate as the alkalizing agent showed a
positive effect on the acid neutralization capacity (20.83mEq) and raft strength (16.95g) as well.
Whereas, the formulation with a higher level of sodium bi-carbonate (4.01%) showed improved
acid neutralization (22.31mEq) but showed a negative effect on raft strengths (10.08g).
Conclusion: Based on the study, the optimum levels include 5% sodium alginate, 1.6% calcium
carbonate and 2.67% sodium bicarbonate to achieve good liquid suspension formulation possessing
good acid neutralization capacity as well as raft strength.