Background: Bone metastasis is common in cancer. Evaluating the metastatic status in
cancer is of utmost importance in order to provide the best patient’s management.
Discussion: Bone scintigraphy is widely used for evaluation of bone metastasis. It has high sensitivity
with limited specificity. Planar bone scintigraphy has been shown to have increased radiotracer
uptake without accurate anatomic localization and characterization. Hybrid Single-Photon Emission
Computed Tomography/Computerized Tomography (SPECT/CT) system has been developed by
combination of SPECT and CT. Accurate lesion localization and discrimination of equivocal bone
lesions is an advantage in this hybrid technique. It improves diagnostic accuracy by differentiation of
benign bone lesions from malignant ones due to their morphological changes. So, SPECT/CT improves
the specificity of bone scintigraphy leading to better outcomes in diagnosis and treatment
outcomes of bone metastatic cancer patients.
Conclusion: In here, we discussed the prognostic value of bone scintigraphy and SPECT/CT in bone
metastasis with our clinical experience and review of the literature.
Keywords: Bone metastasis, bone scintigraphy, cancer, hybrid imaging, SPECT, CT.
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