Background: Multicomponent processes have played powerful roles in achieving
complex structures, which are also aligned with green chemistry. Thus, MCRs have attracted
considerable interest due to their atom economy, simple experimental procedures, automated
synthesis, convenience and synthetic efficiency. Isocyanides are one of the crucial starting material
in designing MCRs methods. They are unique building blocks in many cycloaddition reactions since
they are able to react with both nucleophiles and electrophiles at the same carbon. Furthermore,
ammonium chloride is an inorganic compound that is highly soluble in water, inexpensive and
commercially available. Solutions of ammonium chloride are mildly acidic and have been used in
Objective: This article focuses on design a convenient and straightforward method for assembling
important scaffolds such imidazolidinones through one-pot three-component strategy.
Conclusion: The straightforward and efficient one-pot three component method for the synthesis of
4-(cyclohexylmethylene)-5-phenylimidazolidin-2-one derivatives is described. This reaction exploits
the formation of imine, which undergoes spontaneous intermolecular cycloaddition with isocyanide,
and generates the desired products in a good yield.