Circulating Exosomes as Potential Biomarkers in Cardiovascular Disease

Author(s): Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Maryam Ghandehari, Seyed Mohammad Reza Parizadeh, Seyed Mahdi Hassanian, Majid Rezayi, Majid Ghayour-Mobarhan, Gordon A. Ferns, Amir Avan*

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 37 , 2018


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Abstract:

Cardiovascular disease (CVD) is the first leading cause of morbidity and mortality in developing and developed countries. Circulating exosomes have recently been identified as extracellular transporters, detectable in biological fluids. Exosomes have established a new era in diagnosing diseases, especially CVD. Determination of exosome profiles, e.g., miRNAs, for different health states such as myocardial injury still requires further studies. In this review, we will discuss the role of exosomes as a potential biomarker in CVD, with particular emphasis on recent advances in the methods to study exosomes, isolation, detection, and characterization.

Keywords: Cardiovascular disease, morbidity, mortality, extracellular vesicle, exosome, biomarker.

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Article Details

VOLUME: 24
ISSUE: 37
Year: 2018
Published on: 27 February, 2019
Page: [4436 - 4444]
Pages: 9
DOI: 10.2174/1381612825666181219162655
Price: $65

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