Background: In the present study, a series of substituted naringenin derivatives was synthesized
by Claisen–Schmidt reaction using grinding technique.
Methods: Synthesized compounds were characterized on the basis of Fourier-Transform Infrared Spectroscopy
(FTIR), proton Nuclear Magnetic Resonance (1H NMR), Mass Spectroscopy (MS) and elemental
analysis. These derivatives were screened for anticancer activity on breast (MCF-7) and colon
(HT-29) cell lines using Sulforhodamine B (SRB) colorimetric assay.
Results: Results displayed improved inhibitory concentration (IC50) values of naringenin derivatives.
IC50 values of 3(4-chlorobenzylidene)-5,7-dihydroxy-2(4-hydroxyphenyl)chroman-4-one are 10.35 μM
(MCF-7) & 12.03 μM (HT-29), which is most potent compound in the series. These finding confirms
the suitability of 3-substituted naringenin in improving the anticancer effect.
Conclusion: Due to the intense interest in the development of drugs capable of inhibiting cancerous
cells, naringenin derivatives may represent important precursor molecules for the therapeutic armamentarium
of colon and breast cancer. Further structural modification in these structures will be of interest
and may result in compounds having a better anticancer activity.