A Physical Theory of Sleep Involving Nitrogen Nanobubbles and Proton Hopping

Author(s): Subhash C. Basak, Lemont B. Kier

Journal Name: Current Computer-Aided Drug Design

Volume 15 , Issue 1 , 2019


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[1]
Kier, L.B. Water as a complex system. Its role in ligand diffusion, general anesthesia, and sleep. Chem. Biodiv., 2007, 4(10), 2473-2479.
[2]
Kier, L.B. A review of recent studies relating ligand diffusion, general anesthesia, and sleep. Amer. Assoc. Nurse Anesth. J., 2008, 76, 109.
[3]
Kier, L.B. Theories of ligand diffusion, general anesthesia, and sleep. Anesthesia Research Developments; Nova Science Publ Chapter 1, 2010.
[4]
Kier, L.B. Water chreodes and the mechanism of ligand diffusion, general anesthesia, and sleep. Biochem. Res. Internat., Article ID 396560,
[5]
Kier, L.B. A core molecular theory of sleep and aging. Curr. Computeraided Drug Des., 2012, 8, 87.
[6]
Kier, L.B.; Slattum, P. A core process in receptor function, general anesthesia, sleep and aging. Chem. Biodi., 2012, 9, 930-934.
[7]
Fowler, B.; Ackles, K.N.; Porlier, G. Effects of inert gas narcosis on behavior: A critical review. Undersea Biomed. Res., 1985, 12, 369-402.
[8]
Bennett, P.B. Inert gas narcosis.In: The physiology and medicine of diving; P. B. Bennett, and Elliott D. H. Eds. 4th ed. London: WB Saunders, 1993, pp. 170-193.
[9]
Behnke, A.R.; Thomson, R.M.; Motley, E.P. The psychologic effects from breathing air at 4 atmospheres pressure. Am. J. Physiol., 1935, 112, 554-558.
[10]
Meyer, H. Zur theorie der alkoholnarkose (I): Welche eigenschaft der an¨asthetica bedingt ihre narkotische wirkung. Arch. Exp. Pathol. Pharmakol., 1899, 42, 109-118; Meyer H. Zur theorie der alkoholnarkose (III): der einfluss wechselnder temperature auf wirkungst¨arke und theilungscoefficient der narcotica. Arch. Exp. Pathol. Pharmakol., 1901, 46, 338-346.
[11]
Overton, E. Studien ¨uber die narkose, zugleich ein beitrag zur allgemeiner Pharmakologie; Jena Gustav Fischer, 1901.
[12]
Franks, N.P.; Lieb, W.R. Do general anaesthetics act by competitive binding to specific receptors? Nature, 1984, 310, 599-601.
[13]
Liu, S.; Kawagoe, Y.; Makino, Y.; Oshita, S. Effects of nanobubbles on the physicochemical properties of water: The basis for properties of water containing nanobubbles. Chem. Eng. Sci., 2013, 93, 250-256.
[14]
Ahmed, K.A.A.; Cuizhen, S.; Likun, H.; Zhibin, Z.; Yanhao, Z.; Taha, M.; Wen, Z. Colloidal properties of air, oxygen, and nitrogen nanobubbles in water: Effects of Ionic Strength, Natural Organic Matters, and Surfactants. Environmental. Eng. Sci., 2017.
[http://dx.doi.org/10.1089/ees.2017.0377]
[15]
Zhang, M. Concentration of nitrogen molecules need by nitrogen bubbles existing in bulk water. Appl. Math Mech. Engl. Ed., 2013, 34, 1433-1438.
[16]
Kier, L.B.; Tombes, R. A proposed mechanism for myelinated axon nerve impulses. Chem. Biodivers., 2013, 10, 1155.
[17]
Kier, L.B.; Hall, L.H.; Tombes, R. Enhanced action potential passage through the node of Ranvier in myelinated axons via extracellular proton hopping. Curr. Computeraided Drug Des., 2015, 11, 5-7.
[18]
Kier, L.B. Proton hopping as the nerve conduction message. Curr. Computeraided Drug Des., 2016, 12, 255-258.
[19]
Basak, S.; Kier, L.B. Delving into the fundamental aspects of the drug-receptor interaction. Curr. Computeraided Drug Des., 2017, 13, 87-88.


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Article Details

VOLUME: 15
ISSUE: 1
Year: 2019
Published on: 13 December, 2018
Page: [3 - 5]
Pages: 3
DOI: 10.2174/157340991501181214103920

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