Synthetic Strategies of Benzothiazines: A Mini Review

Author(s): Shafia Mir, Ayaz Mahmood Dar, Bashir Ahmad Dar*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 17 , Issue 2 , 2020


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Graphical Abstract:


Abstract:

Benzothiazine is a heterocyclic compound consisting of a benzene ring attached to the 6- membered thiazine ring. The benzothiazines constitute the group of heterocyclic compounds as they have found a variety of industrial uses and show promise as herbicides. Besides this, benzothiazines play an important role in the field of drug discovery as they have the potential to act as drug candidates for the treatment of a large number of diseases including, cancer, vasorelaxant, diabetic, hypertension, mycotic infection and microbial infection. The presence of nitrogen-sulphur axis and similarity in the structure with phenothiazine drugs help the benzothiazines to act as drugs for the treatment of a number of diseases. Herein, we represent different synthetic strategies for the simple and multi-component synthesis of benzothiazine heterocyclic derivatives. The strategies mostly involve the use of 2-aminothiophenol, 1, 3-dicarbonyl compounds or α-haloketones. In almost all the strategies, the potential yields have been obtained.

Keywords: 2-Aminothiophenol, buchwald coupling, multi-component, benzothiazine, heterocyclic compounds, phenothiazine.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2020
Published on: 28 February, 2020
Page: [148 - 157]
Pages: 10
DOI: 10.2174/1570193X16666181206101439
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