Title:Synthetic Strategies of Benzothiazines: A Mini Review
VOLUME: 17 ISSUE: 2
Author(s):Shafia Mir, Ayaz Mahmood Dar and Bashir Ahmad Dar*
Affiliation:Department of Chemistry, OPJS University, Rajasthan, Department of Chemistry, Govt Degree College Kulgam, Kashmir, Department of Chemistry, Govt Degree College Sopore, Kashmir
Keywords:2-Aminothiophenol, buchwald coupling, multi-component, benzothiazine, heterocyclic compounds, phenothiazine.
Abstract:Benzothiazine is a heterocyclic compound consisting of a benzene ring attached to the 6-
membered thiazine ring. The benzothiazines constitute the group of heterocyclic compounds as they
have found a variety of industrial uses and show promise as herbicides. Besides this, benzothiazines
play an important role in the field of drug discovery as they have the potential to act as drug candidates
for the treatment of a large number of diseases including, cancer, vasorelaxant, diabetic, hypertension,
mycotic infection and microbial infection. The presence of nitrogen-sulphur axis and similarity
in the structure with phenothiazine drugs help the benzothiazines to act as drugs for the treatment
of a number of diseases. Herein, we represent different synthetic strategies for the simple and
multi-component synthesis of benzothiazine heterocyclic derivatives. The strategies mostly involve
the use of 2-aminothiophenol, 1, 3-dicarbonyl compounds or α-haloketones. In almost all the strategies,
the potential yields have been obtained.