New Chalcone Derivative: Synthesis, Characterization, Computational Studies and Antioxidant Activity

Author(s): Reşat Ustabaş, Nevin Süleymanoğlu*, Namık Özdemir, Nuran Kahriman, Ersan Bektaş, Yasemin Ünver

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 1 , 2020


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Abstract:

A new chalcone derivative, called as 1-(4-(benzylideneamino)phenyl)-3-(furan-2-yl)prop-2- en-1-one (I), was synthezised and characterized by spectral methods (infrared (IR) and proton and carbon- 13 nuclear magnetic resonance (1H- and 13C-NMR) spectroscopy). A computational study was performed by the density functional theory (DFT) method. Spectral data of compound I optimized by using 6-311G(d,p) and 6-311++G(d,p) basis sets were obtained by 6-311++G(d,p) basis set. The E-Z isomerism for newly synthesized chalcone derivative was investigated by considering four isomeric form, E/E, E/Z, Z/E and Z/Z. The results show that, as assumed and thus named, the chalcone derivative is in the E/E form. In addition, quantum chemical parameters were calculated by using DFT method with 6-311++G(d,p) basis set. Antioxidant activity of compound I was determined by the ferric reducing ability of plasma (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay methods. Compound I has low antioxidant activity.

Keywords: FTIR and NMR spectroscopy, chalcone derivative, E-Z isomerism, DFT calculations, antioxidant activity, proton.

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Article Details

VOLUME: 17
ISSUE: 1
Year: 2020
Published on: 12 December, 2019
Page: [46 - 53]
Pages: 8
DOI: 10.2174/1570178616666181130163115
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