Histone deacetylases 6 (HDAC6) has emerged as a promising target for the treatment of
various human diseases including cancer, neurodegenerative disease and immunology due to its unique
structure, substrate and biological functions. HDAC6 is involved in cell motility, cell survival, cell
cycle progression, developmental events, prognosis as well as protein degradation and the involvement
of HDAC6 in multiple biological processes has gained lots of attention. There is increasing interest in
HDAC6 and its selective inhibitors. More than twenty years of synthetic efforts have developed various
HDAC6 selective inhibitors with different Cap, linker and ZBG. This review will summarize recent
research data regarding HDAC6 and various HDAC6 selective inhibitors.
Keywords: Epigenetics, HDAC6, Protein degradation, Neurodegenerative disease, Cancer, HDAC6 selective inhibitors.
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