The skin cancer has become a leading concern worldwide as a result of high
mortality rate. The treatment modality involves radiation therapy, chemotherapy or surgery.
More often combination therapy of chemotherapeutic agents gives better solution
over single chemotherapeutic agent. The Globocon report suggested that high incidence
and mortality rate in skin cancer is growing day-to-day. This type of cancer is more prevalent
in that area where a person is highly exposed to sunlight. The nanotechnology-based
therapy is nowadays drawing attention and becoming a more important issue to be discussed.
The nanotherapy of skin cancer is dealt with various approaches and strategies.
The strategic based approaches imply nanoparticles targeting carcinoma cells, functionalized
nanoparticles for specific targeting to cancer cells, receptor-mediated active targeting
as nanoshells, nanostrutured lipid carriers, liposome, ethosome, bilosome, polymeric nanoparticle,
nanosphere, dendrimers, carbon nanotubes, quantum dots, solid lipid nanoparticles
and fullerenes which are highly efficient in specific killing of cancer cells. The passive
targeting of chemotherapeutic agents is also helpful in dealing with carcinoma due to
enhanced permeability and retention effect (EPR).
The article outlines nano-based therapy currently focused globally, and the outcomes of
the therapy as well.