Application of Cell Therapy for Anti-Aging Facial Skin

Author(s): Farshad Zarei, Abolfazl Abbaszadeh*

Journal Name: Current Stem Cell Research & Therapy

Volume 14 , Issue 3 , 2019

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The human skin undergoes the complex process of aging which is prompted by the interplay of intrinsic mechanisms and extrinsic influences. Aging is unavoidable but can be somewhat delayed. Numerous approaches have been developed to slow down facial skin aging process as it is of interest to stake holders in the beauty and fashion world as well as to plastic surgeons. Adipose-derived stem cell [ADSC] and mesenchymal stem cell [MSC] as potential anti-aging agents to some extent have provided a promising and effective alternative in managing skin and facial skin aging. Furthermore, bone marrow-derived mesenchymal stem cells [BMMSC] have exhibited similar ability to rejuvenate aged skin. This review is aimed at giving a comprehensive account of the application of stem cells especially ADSCs and MSCs to reduce or slow down the rate of facial skin aging process.

Keywords: Adipose derived stem cells, mesenchymal stem cells, facial skin, aging, cell therapy, stromal-vascular fraction.

Farage MA, Miller KW, Elsner P, Maibach HI. Functional and physiological characteristics of the aging skin. Aging Clin Exp Res 2008; 20(4): 195-200.
Glogau RG. Physiologic and structural changes associated with aging skin. Dermatol Clin 1997; 15: 555-9.
Zouboulis CC, Makrantonaki E. Clinical aspects and molecular diagnostics of skin aging. Clin Dermatol 2011; 29(1): 3-14.
Cevenini E, Invidia L, Lescai F, et al. Human models of aging and longevity. Expert Opin Biol Ther 2008; 8(9): 1393-405.
Uitto J. Understanding premature skin aging. Mass Medical Soc 1997.
Baumann L. Skin ageing and its treatment. J Pathol 2007; (211): 241-51.
Fisher GJ, Choi H-C, Bata-Csorgo Z, et al. Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo. J Invest Dermatol 2001; 117(2): 219-26.
Griffiths C, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med 1993; 329(8): 530-5.
Varani J, Perone P, Fligiel SEG, Fisher GJ, Voorhees JJ. Inhibition of Type I procollagen production in photodamage: Correlation between presence of high molecular weight collagen fragments and reduced procollagen synthesis. J Invest Dermatol 2002; 119(1): 122-9.
Duncan KO, Leffell DJ. Preoperative assessment of the elderly patient. Dermatol Clin 1997; 15(4): 583-93.
Bonta M, Daina L, Muţiu G. The process of ageing reflected by histological changes in the skin. Rom J Morphol Embryol 2013; 54(3)(Suppl.): 797-804.
Mojallal A, Lequeux C, Shipkov C, et al. Improvement of Skin Quality after Fat Grafting: Clinical Observation and an Animal Study. Plast Reconstr Surg 2009; 124(3): 765-74.
Zarei F, Daraee H. Recent progresses in breast reconstruction: stem cells, biomaterials, and growth factors. Drug Res (Stuttg) 2018; 68(6): 311-6.
Rasmussen JG, Frøbert O, Pilgaard L, et al. Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells. Cytotherapy 2011; 13(3): 318-28.
Kim WS, Park BS, Park SH, Kim HK, Sung JH. Antiwrinkle effect of adipose-derived stem cell: Activation of dermal fibroblast by secretory factors. J Dermatol Sci 2009; 53(2): 96-102.
Rao MS, Mattson MP. Stem cells and aging: Expanding the possibilities. Mech Ageing Dev 2001; 122(7): 713-34.
Crisan M, Yap S, Casteilla L, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008; 3(3): 301-13.
Nowacki M, Kloskowski T, Pietkun K, et al. The use of stem cells in aesthetic dermatology and plastic surgery procedures. A compact review of experimental and clinical applications. Postepy Dermatol Alergol 2017; 34(6): 526.
Ben-David U, Benvenisty N. The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat Rev Cancer 2011; 11(4): 268.
Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger MF. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 2000; 275(13): 9645-52.
Kwon TR, Oh CT, Choi EJ, et al. Conditioned medium from human bone marrow-derived mesenchymal stem cells promotes skin moisturization and effacement of wrinkles in UVB-irradiated SKH-1 hairless mice. Photodermatol Photoimmunol Photomed 2016; 32(3): 120-8.
Ghafarzadeh M, Eatemadi A. Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy. J Cosmet Laser Ther 2017; 19(3): 181-7.
Zarei F, Negahdari B. Recent progresses in plastic surgery using adipose-derived stem cells, biomaterials and growth factors. J Microencapsul 2017; 34(7): 699-706.
Nakagami H, Morishita R, Maeda K, Kikuchi Y, Ogihara T, Kaneda Y. Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy. J Atheroscler Thromb 2006; 13(2): 77-81.
Jung H, Kim HH, Lee DH, Hwang YS, Yang HC, Park JC. Transforming growth factor-beta 1 in adipose derived stem cells conditioned medium is a dominant paracrine mediator determines hyaluronic acid and collagen expression profile. Cytotechnology 2011; 63(1): 57-66.
Skalnikova H, Motlik J, Gadher SJ, Kovarova H. Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines. Proteomics 2011; 11: 691-708.
Xu X, Wang H-Y, Zhang Y, et al. Adipose-derived stem cells cooperate with fractional carbon dioxide laser in antagonizing photoaging: A potential role of Wnt and β-catenin signaling. Cell Biosci 2014; 4(1): 24.
Pawitan JA. Prospect of stem cell conditioned medium in regenerative medicine. BioMed Res Int 2014; 2014: 965849.
Dong L, Hao H, Xia L, et al. Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth. Sci Rep 2014; 4: 5432.
Madonna R, Delli Pizzi S, Tartaro A, De Caterina R. Transplantation of mesenchymal cells improves peripheral limb ischemia in diabetic rats. Mol Biotechnol 2014; 56(5): 438-48.
Chen L, Xu Y, Zhao J, et al. Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice. PLoS One 2014; 9(4): e96161.
Song SY, Jung JE, Jeon YR, Tark KC, Lew DH. Determination of adipose-derived stem cell application on photo-aged fibroblasts, based on paracrine function. Cytotherapy 2011; 13(3): 378-84.
Zhang S, Dong Z, Peng Z, Lu F. Anti-aging effect of adipose-derived stem cells in a mouse model of skin aging induced by D-galactose. PLoS One 2014; 9(5): e97573.
Suga H, Glotzbach JP, Sorkin M, Longaker MT, Gurtner GC. Paracrine mechanism of angiogenesis in adipose-derived stem cell transplantation. Ann Plast Surg 2014; 72(2): 234-41.
Nauta A, Seidel C, Deveza L, et al. Adipose-derived stromal cells overexpressing vascular endothelial growth factor accelerate mouse excisional wound healing. Mol Ther 2013; 21(2): 445-55.
Kapur SK, Katz AJ. Review of the adipose derived stem cell secretome. Biochimie 2013; 95(12): 2222-8.
Zarei F, Soleimaninejad M. Role of growth factors and biomaterials in wound healing. Artif Cells Nanomed Biotechnol 2018. 46(sup1): 906-11.
Hormozi M, Talebi S, Khorram Khorshid HR, et al. The effect of Setarud (IMOD(TM)) on angiogenesis in transplanted human ovarian tissue to nude mice. Iran J Reprod Med 2015; 13(10): 605-14.
Kim W-S, Park B-S, Sung J-H, et al. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci 2007; 48(1): 15-24.
Moradkhani MR, Karimi A. Role of Drug Anesthesia and Cancer. Drug Res (Stuttg) 2018; 68(3): 125-31.
Kraus A, Woon C, Raghavan S, Megerle K, Pham H, Chang J. Co-culture of human adipose-derived stem cells with tenocytes increases proliferation and induces differentiation into a tenogenic lineage. Plast Reconstr Surg 2013; 132(5): 754e-66e.
Desai VD, Hsia HC, Schwarzbauer JE. Reversible modulation of myofibroblast differentiation in adipose-derived mesenchymal stem cells. PLoS One 2014; 9(1): e86865.
Mao G-X, Deng H-B, Yuan L-G, Li D-D, Yvonne Li Y-Y, Wang Z. Protective role of salidroside against aging in a mouse model induced by D-galactose. Biomed Environ Sci 2010; 23(2): 161-6.
Ghafarzadeh M, Eatemadi A. Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy. J Cosmet Laser Ther 2017; 19(3): 181-7.
Coleman SR. Hand rejuvenation with structural fat grafting. Plast Reconstr Surg 2002; 110(7): 1731-44.
Lee MJ, Kim J, Lee KI, Shin JM, Chae JI, Chung HM. Enhancement of wound healing by secretory factors of endothelial precursor cells derived from human embryonic stem cells. Cytotherapy 2011; 13(2): 165-78.
Seo KY, Kim DH, Lee SE, Yoon MS, Lee HJ. Skin rejuvenation by microneedle fractional radiofrequency and a human stem cell conditioned medium in Asian skin: a randomized controlled investigator blinded split-face study. J Cosmet Laser Ther 2013; 15(1): 25-33.
Zarei F, Negahdari B, Eatemadi A. Diabetic ulcer regeneration: Stem cells, biomaterials, growth factors. Artif Cells Nanomed Biotechnol 2018; 46(1): 26-32.
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126(4): 663-76.
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126(4): 663-76.
Zarei F, Abbaszadeh A. Stem cell and skin rejuvenation. J Cosmet Laser Ther 2018; 20(3): 193-7.
Naylor EC, Watson REB, Sherratt MJ. Molecular aspects of skin ageing. Maturitas 2011; 69: 249-56.
Plassais J, Guaguère E, Lagoutte L, et al. A Spontaneous KRT16 mutation in a dog breed: A model for human focal non-epidermolytic palmoplantar keratoderma (FNEPPK). J Invest Dermatol 2015; 135(4): 1187-90.
Harden N. Signaling pathways directing the movement and fusion of epithelial sheets: Lessons from dorsal closure in Drosophila. Differentiation 2002; 70(4-5): 181-203.
Coleman SR. Structural fat grafting: More than a permanent filler. Plast Reconstr Surg 2006; 118(3)(Suppl.): 108S-20S.
Charles-de-Sá L, Gontijo-de-Amorim NF, Maeda Takiya C, et al. Antiaging treatment of the facial skin by fat graft and adipose-derived stem cells. Plast Reconstr Surg 2015; 135(4): 999-1009.
Taee N, Faraji GM, Sherkatolabbasieh Hr. Palmoplantar desquamation and nail shedding follow to hand foot mouth disease. Iran J Pediatr 2014; 24(2): 39-40.
Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol 2012; 4(3): 308-19.

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Article Details

Year: 2019
Page: [244 - 248]
Pages: 5
DOI: 10.2174/1574888X13666181113113415
Price: $65

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