Background and Aim: Lymphoid cell infiltration and destruction of exocrine glands,
specifically lacrimal and salivary glands are characteristics of Sjogren’s syndrome (SS). An etiological
role has been proposed for Helicobacter pylori (H. pylori), interacting in the clinical course
and complications of SS (including gastric cancer and lymphoma). The aim of this study was to
identify the probable correlation between H. pylori infection and Sjogren’s syndrome (SS).
Methods: In this case-control study, ELISA method was used to determine serum level of IgA and
IgM anti H. pylori antibody in 43 subjects with SS according to the international criteria and 95
healthy subjects as control. SPSS-17 was used to analyze data with t-test. P value <0.05 were considered
Results: Serum level of IgM (34.9% vs. 10.5%, p-value= 0.001) and IgA (67.4% vs. 46.3% p
value= 0.021) anti H. pylori antibody were significantly higher in SS patients compared to the control
group. There was a positive correlation between age and H. pylori infection (r=0.2, Pvalue=
Conclusion: Patients with SS had a higher prevalence of H. pylori infection compared to the normal
population. Eradication of H. pylori is recommended particularly in older patients with SS.